Effect of narrow-band ultraviolet B phototherapy combined with enteric-coated thymopeptide on VCAM-1 and ICAM-1 in patients with pityriasis rosea
10.3969/j.issn.1009-0754.2025.02.016
- VernacularTitle:窄谱中波紫外线照射联合胸腺肽肠溶片治疗对玫瑰糠疹患者VCAM-l和ICAM-1水平的影响
- Author:
Jinshu YU
1
;
Dongling GU
;
Weihua XU
;
Minmin ZHANG
Author Information
1. 226100 江苏 南通,海门区人民医院皮肤科
- Keywords:
Pityriasis rosea;
Narrow-band ultraviolet B phototherapy;
Enteric-coated thymopeptide;
Vascular cell adhesion molecule-1;
Intercellular adhesion molecule-1
- From:
Journal of Navy Medicine
2025;46(2):179-183
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy of narrow-band ultraviolet B(NB-UVB)phototherapy combined with enteric-coated thymopeptide in treatment of pityriasis rosea and its impacts on vascular cell adhesion molecule-1(VCAM-1)and intercellular adhesion molecule-1(ICAM-1).Methods Eighty patients with pityriasis rosea who were admitted to Haimen District People's Hospital from September 2022 to February 2024 were selected as research objects.They were divided into treatment group(n=41)and control group(n=39)according to random number table method.The control group was treated with NB-UVB phototherapy for one month,and the treatment group received NB-UVB phototherapy and enteric-coated thymopeptide for one month.The efficacy,rash-related time changes,symptom improvement,Pityriasis Rosea Severity Score(PRSS),VCAM-1 and ICAM-1 levels,and adverse events were compared between the two groups.Results The total effective rate of the treatment group was higher than that of the control group.The skin rash came to a halt and disappeared in a shorter time in the treatment group than in the control group,while the time to itch cessation in the treatment group was significantly longer than that in the control group(all P<0.05).The PRSS scores and levels of VCAM-1 and ICAM-1 in the treatment group were lower than those in the control group after treatment(all P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion NB-UVB phototherapy combined with enteric-coated thymopeptide can enhance the therapeutic effects on pityriasis rosea and reduce VCAM-1 and ICAM-1 levels.
