Preparation of Xuanyang Jiedu cream and its pharmacodynamics
10.3969/j.issn.1009-0754.2025.01.012
- VernacularTitle:癣痒解毒乳膏的制备工艺研究及药效学初探
- Author:
Qinwufeng GU
1
;
Hanwen ZHANG
;
Tingru CHEN
;
Yuanyuan MENG
;
Yunyang WU
;
Yanlong YANG
Author Information
1. 200433 上海,海军军医大学第一附属医院中医外科
- Keywords:
Skin superficial mycosis;
Xuanyang Jiedu formula;
Traditional Chinese medicine;
Cream
- From:
Journal of Navy Medicine
2025;46(1):52-56
- CountryChina
- Language:Chinese
-
Abstract:
Objective To prepare Xuanyang Jiedu cream and to study its pharmacodynamics.Methods The herbal decoction process of Xuanyang Jiedu cream was optimized by orthogonal design method.The prescription of the cream preparation was screened according to the external properties,malleability and stability of cream.Forty normal guinea pig were randomly divided into four groups(10 in each group):blank group,model group,ketoconazole cream group,and Xuanyang Jiedu cream group.The guinea pig model of tinea corporis was established to investigate the efficacy of Xuanyang Jiedu cream in the treatment of superficial fungal disease.Results The optimal extraction conditions were 3 extractions,water added for 20 times,and 1.5 h of extraction time.The number of extractions and the amount of water significantly affected on the extraction process of the liquid extract.The optimized Xuanyang Jiedu cream looked smooth and creamy,with moderate viscosity and good stabilities of centrifuge,cold and heat resistance.After 14 d treatment,there were still obvious erythema,scales and papules on the lesions in the model group.The scores of erythema,scales and papules in the Xuanyang Jiedu cream group and the ketoconazole cream group were lower than those in the model group(P<0.05).Conclusion Xuanyang Jiedu cream has antifungal activity and may be a new treatment for skin superficial mycosis.
