Clinical value of neutrophil/lymphocyte ratio in predicting encephaledema and prognosis in elderly patients with hypertensive cerebral hemorrhage
10.3969/j.issn.1009-0754.2024.11.011
- VernacularTitle:中性粒细胞/淋巴细胞比值预测老年高血压性脑出血患者脑水肿及预后的临床价值
- Author:
Han ZHANG
1
;
Jun LI
;
Xiaojiang LIU
;
Yixiang GUAN
Author Information
1. 226600 江苏 海安,海安市人民医院神经外科
- Keywords:
Neutrophil/lymphocyte ratio;
Elderly;
Cerebral hemorrhage;
Encephaledema;
Prognosis
- From:
Journal of Navy Medicine
2024;45(11):1153-1157
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between neutrophil/lymphocyte ratio(NLR)and the degree of encephaledema in elderly patients with hypertensive intracerebral hemorrhage(HICH),and the clinical value of NLR in predicting short-term prognosis.Methods From January 2018 to December 2021,113 elderly HICH patients were evaluated by modified Rankin scale(mRS).According to the median mRS score,the patients were divided into poor prognosis group and good prognosis group.Spearman correlation analysis was used to test the correlation between mRS score and clinical laboratory indexes and the severity of early encephaledema.Multivariate logistic regression analysis was used to assess risk factors of prognosis.Results Compared with the good prognosis group,the poor prognosis group had higher proportion of patients with a history of diabetes mellitus and moderate/severe encephaledema,lower levels of white blood cell(WBC)and lymphocyte(LY),higher NLR level and more bleeding volume(P<0.05).The history of diabetes,LY count,NLR and the degree of encephaledema were independent factors affecting the short-term prognosis of patients.The model combining NLR,diabetes mellitus history and encephaledema could effectively predict the short-term prognosis of elderly HICH patients(area under curve value 0.868).There was a significant positive correlation between NLR and the degree of secondary encephaledema.Conclusion The degree of secondary encephaledema and short-term prognosis of elderly HICH patients are closely related to clinical predictors such as NLR,which provides a theoretical basis for individualized treatment and early prevention of encephaledema in these patients.
