Effects of dapagliflozin and sitagliptin combined with metformin on glucose and lipid metabolism and inflammatory reaction in obese type 2 diabetes patients
10.3969/j.issn.1009-0754.2024.09.015
- VernacularTitle:达格列净、西格列汀分别联合二甲双胍在肥胖型2型糖尿病患者糖脂代谢及炎症反应中的影响比较
- Author:
Zhen LI
1
;
Fei WU
;
Mei ZHANG
;
Taomei XIE
Author Information
1. 571700 海南 儋州,儋州市人民医院内分泌代谢科
- Keywords:
Obesity;
Type 2 diabetes;
Dapagliflozin;
Sitagliptin;
Metformin;
Glucose and lipid metabolism;
Inflammatory reaction
- From:
Journal of Navy Medicine
2024;45(9):955-959
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the effects of dapagliflozin and sitagliptin combined with metformin on glucose and lipid metabolism and inflammatory reaction in obese type 2 diabetes patients.Methods A total of 120 obese type 2 diabetes patients treated in Danzhou People's Hospital from January 2019 to January 2022 were divided into observation group(dapagliflozin+metformin)and control group(sitagliptin+metformin).The indexes of glucose and lipid metabolism and serum inflammatory factors were recorded before and after treatment.The curative effect was compared between the two groups.Results The curative effect of the observation group was significantly higher than that of the control group(96.67%vs.83.33%,P<0.05).There were no significant differences in the indexes of glucose and lipid metabolism or the levels of serum inflammatory factors between the two groups before treatment(all P>0.05).Fasting blood glucose(FBG),2-hour postprandial blood glucose(2 hPBG),glycosylated hemoglobin(HbA1c),total cholesterol(TC),triglyceride(TG),low-density lipoprotein cholesterol(LDL-C),interleukin-6(IL-6),tumor necrosis factor α(TNF-α)and C-reactive protein(CRP)were significantly decreased after treatment in both groups,and high-density lipoprotein cholesterol(HDL-C)was significantly increased(all P<0.05).The observation group had lower levels of FBG,2 hPBG,HbA1c,TC,TG,LDL-C,IL-6,TNF-α and CRP and higher level of HDL-C than control group after treatment(all P<0.05).Conclusion Both dapagliflozin and sitagliptin combined with metformin are effective for the treatment of obese type 2 diabetes.But the combined use of dapagliflozin and metformin is more effective;it can effectively improve the glucose and lipid metabolism and reduce the level of inflammatory factors,making it worthy of clinical promotion.
