Efficacies of palonosetron,tropisetron and ondansetron in preventing vomiting after transcatheter arterial chemoembolization
10.3969/j.issn.1009-0754.2024.08.018
- VernacularTitle:帕洛诺司琼、托烷司琼、昂丹司琼预防肝动脉化疗栓塞术后所致呕吐疗效的临床观察
- Author:
Shuang WU
1
;
Dan WU
;
Yixiang SHI
Author Information
1. 200433 上海,海军军医大学第一附属医院介入治疗科
- Keywords:
Liver metastasis;
Transarterial chemoembolization;
Palonosetron;
Vomit
- From:
Journal of Navy Medicine
2024;45(8):857-860
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the efficacies and adverse reactions of palonosetron hydrochloride with tropisetron and ondansetron in the prevention of nausea and vomiting after transcatheter arterial chemoembolization.Methods A total of 120 patients with postoperative liver metastasis of colorectal cancer who underwent transcatheter arterial chemoembolization were randomly divided into three groups.One hour before surgery,tropisetron hydrochloride(5 mg)was intravenously dripped in group A,ondansetron hydrochloride capsule(8 mg)was orally administered in group B,and palonosetron hydrochloride(0.25 mg)was intravenously injected in group C.No other antiemetics were used after surgery,and if necessary,intramuscular injection of metoclopramide(10 mg)was given for rescue.Results The complete response rates in preventing acute vomiting were 67.5%in group A,65.0%in group B,and 70.0%in group C,with no statistically significant difference(P>0.05).The complete response rate in preventing delayed vomiting was 87.5%in group C,which was significantly higher than those in group A(70.0%)and group B(60.0%)(P<0.05).The main adverse reactions in the three groups were mild constipation and abdominal distension.Conclusion Palonosetron,tropisetron,and ondansetron have satisfactory effects on preventing postoperative nausea and vomiting caused by transcatheter arterial chemoembolization,with mild and controllable adverse reactions.Palonosetron hydrochloride has a better effect on delayed vomiting.
