Evaluation of NAFLD in non-obese type 2 diabetes mellitus patients based on insulin resistance proxies

VernacularTitle:基于胰岛素抵抗替代指标评估非肥胖2型糖尿病患者NAFLD的价值
Author: Mengting LI ¹ ; Bi LU ; Yan ZHANG ; Lin JIANG
Author Information

1. 215600 江苏苏州,张家港澳洋医院风湿免疫内分泌科
Keywords: Type 2 diabetes mellitus; Insulin resistance proxies; Non-alcoholic fatty liver disease
From: Journal of Navy Medicine 2024;45(7):739-744
CountryChina
Language:Chinese
Abstract: Objective To investigate the value of proxies for insulin resistance in evaluating non-alcoholic fatty liver disease visceral fat index(VAI)(OR=3.777,95%CI:1.554-9.180)were the influencing factors of NAFLD in T2DM patients(all P<0.05).Receiver operating character(ROC)curve showed that the sensitivities of HOMA-IR,TG/HDL-C,TyG,TyG-BMI and VAI in predicting NAFLD in T2DM patients was 71.43%,74.79%,71.43%,73.95%and 70.59%,specificity were 70.73%,80.49%,73.17%,79.27%and 70.73%,and AUC values were 0.744,0.758,0.742,0.777 and 0.724,respectively.The levels of HOMA-IR,TG/HDL-C,TyG and TyG-BMI in the progressive liver fibrosis group were higher than those in the non-progressive liver fibrosis group(all P<0.05).Conclusion Homa-IR,TG/HDL-C,TyG,TyG-BMI and VAI are associated with NAFLD in T2DM patients.Insulin resistance proxies show good efficacy in predicting NAFLD in T2DM patients,and it may be related to the severity of NAFLD.