Expression of TLR4 and COX-2 in tissue of breast cancer after surgery and their effects on microangiogenesis
10.3969/j.issn.1009-0754.2024.07.008
- VernacularTitle:TLR4、COX-2在乳腺癌术后组织内的表达及对微血管生成的影响
- Author:
Hongying QING
1
;
Yi LUO
;
Kepeng ZHU
Author Information
1. 637000 四川 南充,南充市中心医院乳腺血管外科
- Keywords:
Breast cancer;
Toll-like receptor 4;
Cyclooxygenase 2;
Angiogenesis;
Correlation
- From:
Journal of Navy Medicine
2024;45(7):705-709
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of Toll-like receptor 4(TLR4)and cyclooxygenase-2(COX-2)in the tissue of breast cancer after surgery and their effects on angiogenesis.Methods Totally 60 patients with breast cancer treated in the Nanchong Central Hospital from April 2021 to April 2022 were selected as research subjects.After surgical treatment,the samples of cancer tissues and normal tissue adjacent to the cancer were taken for study.The expression of COX-2,TLR4 and microvessel density(MVD)in the tissues were detected by immunohistochemical method.The factors affecting the expression of COX-2,TLR4 and their relationship with angiogenesis in the tissues of breast cancer after surgery were analyzed.Results The positive expression of COX-2,TLR and MVD in the breast cancer tissue was significantly higher than those in the adjacent normal tissue(P<0.05).Univariate analysis revealed that the proportions of tumor diameter>2 cm,clinical stage III-IV lymph and node metastasis in the breast cancer tissues were significantly higher than those in the negative expression(P<0.05).Multivariate Logistic regression analysis showed that tumor diameter>2 cm,clinical stage III-IV and lymph node metastasis were the risk factors for the positive expression of COX-2 and TLR4 in the tissue of breast cancer after surgery(P<0.05).The MVD level of TLR4 and COX-2 positive expression in breast cancer tissue was significantly higher than that of the negative expression(P<0.05).Conclusion The high expression levels of COX-2 and TLR4 in the breast breast cancer tissue after surgery are closely related to angiogenesis,which might promote the development of the disease.
