Effect of hydrogen sulfide inhalation on olfactory function in mice
10.3969/j.issn.1009-0754.2024.07.005
- VernacularTitle:硫化氢吸入染毒对小鼠嗅觉功能影响研究
- Author:
Liben FANG
1
;
Xiaomeng REN
;
Xinhong XU
;
Lu JIANG
;
Jingjing FANG
Author Information
1. 200433 上海,海军军医大学海军特色医学中心
- Keywords:
Hydrogen sulfide;
Olfaction;
Poisoning
- From:
Journal of Navy Medicine
2024;45(7):690-694
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of hydrogen sulfide(H2S)on olfactory function in mice and the recovery of olfactory function after H2S poisoning test.Methods Thirty-six clean grade BALB/c mice were randomly divided into control group,0.05 mg/L H2S exposure group,and 5.00 mg/L H2S exposure group according to the random number table method,with 12 mice in each group.The recovery of olfactory function was observed after H2S exposure cycle.The behavior and foraging time of the mice were recorded.Results Before the exposure test,there was no significant difference in olfaction time among the groups(P>0.05).On the 10th,20th and 30th day of the exposure test,the foraging time of 5.00 mg/L H2S exposure group was gradually prolonged,which was significantly different from that of the control group and 0.05 mg/L H2S exposure group(P<0.05).On the 5th,10th and 15th day after exposure test,the foraging time of 5.00 mg/L H2S exposure group gradually shortened,which was significantly longer than that of the control group and 0.05 mg/L H2S exposure group(P<0.05).Conclusion The short-term toxicity test of 5.00 mg/L H2S can cause olfactory dysfunction in mice,manifested by differences in foraging time.This olfactory dysfunction can be recovered to some extent within 15 days after leaving the exposed environment.
