Early diagnosis of ectopic pregnancy by transvaginal three-dimensional ultrasound combined with serum CA125,VEGF and AMH
10.3969/j.issn.1009-0754.2024.06.019
- VernacularTitle:经阴道三维超声联合血清糖类抗原125、血管内皮生长因子和抗米勒管激素对异位妊娠的早期诊断价值研究
- Author:
Fucai QIN
1
;
Yonggao XIE
Author Information
1. 430000 湖北 武汉,湖北省中西医结合医院超声影像科
- Keywords:
Transvaginal three-dimensional ultrasound;
Carbohydrate antigen 125;
Vascular endothelial growth factor;
Anti-Müllerian hormone;
Ectopic pregnancy
- From:
Journal of Navy Medicine
2024;45(6):643-647
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the early diagnosis of ectopic pregnancy by transvaginal three-dimensional ultrasound combined with serum carbohydrate antigen 125(CA125),vascular endothelial growth factor(VEGF)and anti-Müllerian hormone(AMH).Methods Totally 96 patients with ectopic pregnancy and 48 pregnant women with normal intrauterine pregnancy diagnosed and treated from May 2019 to June 2022 were selected as study objects.Ultrasonographic parameters(vascularization index[VI],flow index[FI],vascularization flow index[VFI]),and serum CA125,VEGF and AMH were compared between ectopic pregnancy group and intrauterine pregnancy group.Logistic regression model was used to construct diagnostic models by ultrasonic parameters,serum CA125,VEGF and AMH ultrasonic parameters,serum CA125,VEGF and AMH,and six combined parameters.Receiver operating characteristic(ROC)curve was used to evaluate the area under the curve(AUC)values,sensitivities and specificities of ultrasonic parameters(VI,FI,VFI),CA125,VEGF,AMH,and six combined parameters for the diagnosis of ectopic pregnancy.Results The ectopic pregnancy group had lower VI,FI,VFI and AMH and higher CA125 and VEGF than the intrauterine pregnancy group(all P<0.05).ROC curve analysis showed that the AUC of VI,FI,VFI,CA125,VEGF,AMH and combined parameters for the diagnosis of ectopic pregnancy were 0.753,0.644,0.765,0.763,0.768,0.739 and 0.995,respectively.The AUC of the combined parameters was larger than those of VI,FI,VFI,CA125,VEGF and AMH(P<0.05).Conclusion Transvaginal three-dimensional ultrasound combined with serum CA125,VEGF and AMH has high diagnostic value for early ectopic pregnancy and is worthy of clinical application.
