Clinical application of Shufeng Jiedu capsule combined with Budesonide inhalation aerosol in acute exacerbation of chronic obstructive pulmonary disease
10.3969/j.issn.1009-0754.2024.05.021
- VernacularTitle:疏风解毒胶囊联合布地格福吸入气雾剂在慢性阻塞性肺疾病急性加重期中的临床应用
- Author:
Fan LI
1
;
Yan ZHANG
;
Wanxun LIU
;
Xiaohua LIU
Author Information
1. 621000 四川绵阳,四川绵阳四0四医院(绵阳市第一人民医院)呼吸与危重症医学科
- Keywords:
Shufeng Jiedu Capsule;
Budesonide inhalation aerosol;
Chronic obstructive pulmonary disease;
Acute exacerbation;
Clinical effect
- From:
Journal of Navy Medicine
2024;45(5):526-530
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the clinical effect of Shufeng Jiedu capsule combined with Budesonide inhalation aerosol on acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods A total of 122 AECOPD patients admitted to the 404th Hospital of Mianyang,Sichuan Province from February 2022 to January 2023 were selected and divided into study group(n=61)and control group(n=61)by random number table method.All the patients received standardized basic treatment.The control group was also given Budesonide inhalation aerosol,and the study group was given Shufeng Jiedu capsule plus Budesonide inhalation aerosol.The patients in both groups were treated for 14 d.The clinical efficacy,forced expiratory volume in one second(FEV1),peak expiratory flow(PEF),forced vital capacity(FVC),serum C-reactive protein(CRP),serum amyloid A(SAA),serum procalcitonin(PCT),airway wall thickness-diameter ratio(TDR),percentage of wall area(WA)and drug safety were compared between the two groups.Results The total effective rate of the study group was significantly higher than that of the control group(93.44%vs.75.41%,P<0.05).After treatment,the levels of FEV1,PEF and FVC were increased in both groups(P<0.05),especially in the study group(P<0.05).After treatment,serum levels of CRP,SAA and PCT,TDR and WA were decreased in both groups(P<0.05),especially in the study group(all P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Shufeng Jiedu Capsule combined with Budesonide inhalation aerosol is effective,safe and reliable in the treatment of AECOPD.It can improve lung function and airway remodeling indexes,alleviate inflammation and reduce SAA level.
