Effects of Bushen ovulation-stimulating decoction on oocyte quality and pregnancy outcome of IVF-ET in patients with repeated transplantation failure
10.3969/j.issn.1009-0754.2024.01.015
- VernacularTitle:补肾促排卵汤对反复移植失败患者卵子质量及体外受精-胚胎移植妊娠结局的影响
- Author:
Yangyang CUI
1
;
Feng TIAN
;
Wenhua WANG
Author Information
1. 030600 山西 晋中,晋中婴泰妇产医院生殖医学科
- Keywords:
Bushen ovulation-stimulating decoction;
Infertility;
In vitro fertilization-embryo transfer;
Oocyte quality;
Pregnancy outcome
- From:
Journal of Navy Medicine
2024;45(1):76-80
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effects of Bushen ovulation-stimulating decoction on oocyte quality and pregnancy outcome of in vitro fertilization-embryo transfer(IVF-ET)in patients with repeated transplantation failure.Methods From January 2019 to January 2021,86 patients who received IVF-ET again because of repeated transplantation failure in Jinzhong Yingtai Women's&Children's Hospital were randomly divided into control group and observation group,with 43 cases in each group.Progesterone was given 2 days before IVF-ET treatment in both groups,and the observation group was additionally treated with Bushen ovulation-stimulating decoction at the peak of luteinizing hormone in menstrual cycle before transplantation.All the patients in both groups were treated continuously for 3 menstrual cycles.Traditional Chinese medicine symptom score,hormone level,oocyte quality,endometrium and blood flow were observed and compared between the 2 groups.Results After 3 menstrual cycles of treatment,the scores of pale menstrual color,soreness and softness of waist and knees,and dryness in the vagina in the observation group were significantly lower than those in the control group(P<0.05).Three weeks after transplant,the observation group had significantly higher levels of serum progesterone(P)and estradiol(E2)and lower level of follicle stimulating hormone(FSH)than the control group(all P<0.05).On the day of ovulation,the thickness of endometrium in the observation group was significantly higher than that in the control group,and the resistance index(RI)and pulsatility index(PI)of uterine artery in the observation group were significantly lower than those in the control group(P<0.05).The fertilization rate,the number of ovum obtained,clinical pregnancy rate,average gestational weeks of delivery,neonatal weight and one-minute Apgar score in the observation group were significantly higher than those in the control group(P<0.05).The early abortion rate and fetal preterm birth rate in the observation group were significantly lower than those in the control group(P<0.05).Conclusion Bushen ovulation-stimulating decoction can significantly increase the scores of traditional Chinese medicine symptoms,improve blood circulation of uterus,gonadal hormone concentrations and oocyte quality,and reduce the incidence of adverse pregnancy outcomes in patients who repeatedly fail to receive IVF-ET treatment.
