Risk factors of senile degenerative heart valve disease in elderly people in China:a Meta-analysis
10.3969/j.issn.1009-0754.2024.01.008
- VernacularTitle:中国老年人退行性心脏瓣膜病临床危险因素的Meta分析
- Author:
Mengqiao DAI
1
;
Xiaoqin LIAO
;
Shan HUA
Author Information
1. 201203 上海,上海中医药大学护理学院
- Keywords:
China area;
Elderly;
Senile degenerative heart valve disease;
Risk factors;
Meta analysis
- From:
Journal of Navy Medicine
2024;45(1):31-40
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore risk factors of senile degenerative heart valve disease(SDHVD)in the elderly in China by Meta analysis.Methods Meta-analysis was conducted according to preferred reporting items for systematic reviews and Meta-analyses(PRISMA)guidelines for systematic review and Meta-analysis.Eleven electronic databases,including PubMed,Web of Science,Cochrane,Embase,Ovid,Scopus,CNKI,VIP database,Wan Fang database,The National Medical Journal of China,and SinoMed database,were retrieved from their inception to March 15,2023.The articles about SDHVD were searched systematically.Literature screening,quality evaluation and data extraction were independently conducted by 2 researchers according to the inclusion and exclusion criteria.Meta-analysis was performed by Stata17.0.Results A total of 18 articles(including cross-sectional study and case-control study)were included,involving 10 121 elderly people.After controlling the confounding variables,the following risk factors were related to SDHVD in elderly people in China:age(WMD=4.29,95% CI:1.84-6.74,I2=94.5% ,P<0.05),smoking(OR= 1.32,95% CI:1.00-1.73,I2=78.9% ,P<0.05),hypertension(OR=1.93,95% CI:1.75-2.13,I2=0,P<0.001),hyperlipidemia(OR=1.66,95% CI:1.40-1.97,I2=2.4% ,P<0.001),diabetes mellitus(OR=1.33,95% CI:1.05-1.69,I2=60.6% ,P<0.05),coronary artery disease(OR=2.12,95% CI:1.60-2.80,I2=67.4% ,P<0.001),osteoporosis(OR=3.42,95% CI:2.07-5.65,I2= 0,P<0.001),blood phosphorus(OR=-0.02,95% CI:-0.05-0.02,I2=0,P>0.05).Conclusion Age,smoking,hypertension,hyperlipidemia,diabetes mellitus,coronary artery disease,and osteoporosis are the risk factors of SDHVD in elderly people.
