Value of serum tumor markers combined with microRNA-1246 in evaluating of sensitivity of concomitant radiochemotherapy for locally advanced non-small cell lung cancer
10.3969/j.issn.1009-0754.2023.12.010
- VernacularTitle:血清肿瘤标志物联合microRNA-1246检测对局部晚期非小细胞肺癌同步放化疗敏感性的评估价值
- Author:
Xiangjian CHU
1
;
Haiyan CAO
;
Meiyun DAI
Author Information
1. 226500 江苏 如皋,如皋市人民医院放疗科
- Keywords:
Tumor markers;
MicroRNA-1246;
Non-small cell lung cancer;
Concomitant radiochemotherapy;
Sensitivity
- From:
Journal of Navy Medicine
2023;44(12):1259-1263
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the value of serum tumor markers combined with microRNA(miR)-1246 in evaluating the sensitivity of concomitant radiochemotherapy(CCRT)for locally advanced non-small cell lung cancer(NSCLC).Methods The clinical data of 110 NSCLC patients admitted to The People's Hospital of Rugao from March 2019 to March 2022 were collected.All the patients underwent CCRT and were divided into sensitive group(complete or partial response)and insensitive group(stable or progressive disease)according to therapeutic effects 1 month after treatment.The clinical data of the 2 groups were detected at admission.The levels of serum tumor markers and miR-1246 at admission and after treatment were compared between the 2 groups.Logistic regression analysis was used to analyze the influence factors of CCRT sensitivity in NSCLC patients,and receiver operating characteristics(ROC)curve was used to analyze the predictive value of serum tumor markers combined with miR-1246 on CCRT sensitivity in NSCLC patients.Results One month after treatment,47 patients had a complete or partial response and 63 patients had stable or progressive disease.The serum levels of neuronal enolase(NSE),carcinoembryonic antigen(CEA),carbohydrate antigen 125(CA125)and miR-1246 in the insensitive group were significantly higher than those in the sensitive group(P<0.05).Logistic regression analysis showed that NSE,CEA,CA125,and miR-1246 were independent risk factors for CCRT sensitivity(P<0.05).ROC curve analysis showed that the area under the curve(AUC)values of NSE,CEA,CA125,and miR-1246 alone in evaluating CCRT sensitivity were 0.790(95%CI:0.702-0.862),0.816(95%CI:0.731-0.884),0.800(95%CI:0.713-0.870),and 0.795(95%CI:0.711-0.869),respectively.The AUC value of the combined assessment of the above 4 indexes was 0.923(95%CI:0.857-0.965).Conclusion Both serum tumor markers and miR-1246 are valuable for assessing CCRT sensitivity in NSCLC patients,and their combination has a higher value for assessing CCRT sensitivity.
