Clinical characteristics and follow-up after treatment of systemic lupus erythematosus in children and adults:a comparative analysis
10.3969/j.issn.1009-0754.2023.11.009
- VernacularTitle:儿童与成人系统性红斑狼疮临床特征和治疗后随访的对比分析
- Author:
Xunwei LIU
1
;
Lingyun YANG
;
Liping ZHAO
Author Information
1. 214000 江苏 无锡,无锡市儿童医院儿肾脏风湿免疫科
- Keywords:
Systemic lupus erythematosus;
Children;
Adults
- From:
Journal of Navy Medicine
2023;44(11):1142-1146
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the condition and prognosis of systemic lupus erythematosus(SLE)between children and adults.Methods A total of 196 patients diagnosed as SLE in Wuxi Children's Hospital and Wuxi People's Hospital from January 2015 to December 2021 were enrolled.They were assigned to children group(n=67)on adult group(n=129).Clinical characteristics and laboratory data of the patients at the onset of the disease and data during follow-up were recorded and compared between the two groups.Results The incidence of infection,the rate of kidney involvement,the number of organs involved,and the positive rate of anti-nucleosome antibody at onset in the children group were higher than those in the adult group(P<0.05).The SLE disease activity index and the average daily dose of glucocorticoid of the children group were significantly higher than those of the adult group at onset,1-month of follow-up,6-month of follow-up,and 1-year of follow-up(P<0.05).The results of Eysenck personality questionnaire showed that the children group had lower score of E scale and higher score of N scale than the adult group(both P<0.05).Conclusion There are certain differences in clinical manifestations between children and adults with SLE.Children have higher SLE activity and need longer recovery time than adults.It is essential to strengthen the monitoring of glucocorticoid side effects and psychological issues in children with SLE during follow-up.
