Correlation between infectious fever and liver failure in the patients with hepatitis B
10.3969/j.issn.1009-0754.2018.02.023
- VernacularTitle:乙型肝炎患者感染性发热与肝衰竭的相关性分析
- Author:
Yunfei LUO
1
;
Zhen GONG
;
Aihua DONG
;
Chi WANG
Author Information
1. 当阳市人民医院感染科
- Keywords:
Acute hepatitis B;
Fever;
Liver failure;
Correlation
- From:
Journal of Navy Medicine
2018;39(2):165-167,后插2
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe influential febrile factors in the precursors of the patients with acute hepatitis B , and also to analyze the effects of infectious febrile on the disease course of acute hepatic failure .Methods An investigation was made on the 210 patients with acute hepatitis B treated in the hospital from January 2013 to January 2017 and the patients were divided into the fever group and the control group by depending on whether or not they had fever at the initial stage , each consisting of 105 patients.Serum biochemical indexes were compared between the two groups , then, the association of related factors between fever and acute liver failure was analyzed by using multiple factor Logist regression method .Results In the fever group, alanine aminotransferase (ALT), total bil-irubin (TBIL) and INR were higher than those of the control group , and albumin, HBeAg positive rate and HBsAg >250 IU/ml were lower than those of the control group (P<0.05).There was no statistical significance between HBV and DNA (P>0.05).The inci-dence of acute liver failure in the fever group was higher than that in the control group (P<0.05), but there was no significant differ-ence in liver failure mortality (P>0.05).Logist multivariate analysis showed that albumin level was lower than 40 g/L, INR was high-er than 1.1 and platelet was lower than150 ×109/L.Negative HBeAg at admission of hospital was an independent risk factor of acute hepatitis B fever at the initial stage .Multi-factor Logist regression analysis revealed that fever at the initial stage was an independent risk factor for acute liver failure .Conclusion There was a clear correlation between fever at the initial stage and liver failure in the patients with acute hepatitis B .For this reason , clinicians should be highly aware , so as to avoid occurrence of such adverse events .
