Effect of Tianxiang capsules on the behavior of rats with motion sickness and related mechanism
10.3969/j.issn.1009-0754.2018.01.010
- VernacularTitle:天香胶囊对运动病模型大鼠行为学的影响及其机制
- Author:
Weiyue ZHANG
1
;
Weihong LI
;
Yanhong HU
;
Fan ZHANG
;
Wei ZHANG
;
Ning DAI
;
Feng LI
Author Information
1. 北京中医药大学中医学院
- Keywords:
Tianxiang capsule;
Motion sickness;
Spontaneous activity;
Stress response
- From:
Journal of Navy Medicine
2018;39(1):25-28
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of Tianxiang capsules on the behavior of rats with motion sickness and its related mechanism.Methods A total of 60 male SD rats were randomly divided into 6 groups:the blank control group,the model group,the scopolamine group(or the positive control group), the Tianxiang low, moderate and high dosage groups, each consisting of 10 rats. Rats in each group were given medication 1 hour before development of the model,and the animals were exposed continuously to rotating stimulation for 2 hours by using a rotational stimulation device,and the motion sickness model was thus developed.Spontaneous activity was used to observe changes in the behavior of rats,the levels of acetylcholine(ACh), adrenocorticotropic hormone(ACTH)and β-endorphin(β-EP)were detected by using ELISA and radioimmunoassay.Results Total distance and duration of spontaneous activity of the rats in the 3 different Tianxiang dosage groups were all increased to various extents,and the levels of ACTH,β-EP and ACh were decreased in vestibular nucleus,and a dose-dependent relationship could clearly be seen.Conclusion The Tianxiang capsule could significantly improve the spontaneous activity of the rats with motion sickness,the intrinsic mechanism might be related to the decrease of excitability of central nervous system,and the reduction of plasma ACTH,β-EP and ACh levels of vestibular nucleus.It was indica-ted that the compound Tianxiang capsule had certain prevention and treatment effects on motion sickness,and high dosage could produce most significant effects on the model rats,and it was obviously the optimal dosage.
