Infection and drug resistance of staphylococcus aureus in patients with hospital-acquired pneumonia
10.3969/j.issn.1009-0754.2017.06.017
- VernacularTitle:某院336例医院获得性肺炎患者金黄色葡萄球菌感染情况及耐药性研究
- Author:
Anshan ZHUO
1
;
Zhengbiao GUAN
;
Yi LI
;
Shilin XU
;
Wanning TONG
;
Xing SUN
;
Hongxia ZHAO
;
Lei LI
Author Information
1. 解放军第四一一医院呼吸科
- Keywords:
Hospital-acquired pneumonia;
Staphylococcus aureus;
Methicillin resistance;
Drug resistance
- From:
Journal of Navy Medicine
2017;38(6):527-529
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the infection distribution of the hospital-acquired pneumonia (HAP) in patients with Staphylococcus aureus (S.aureus) and its drug resistance to those commonly-used antimicrobial agents, so as to provide evidence for rational use of antibacterial drugs clinically .Methods Retrospective analysis of the infection status and drug resistance of Staphylococ-cus aureus in 336 cases of HAP treated in the hospital from January 2011 to December 2015 was made in the study .Results (1) Nine-ty-three strains of Staphylococcus aureus were isolated from the 336 cases of HAP (27.7%), including 78 strains of methicillin-resist-ant Staphylococcus aureus (MRSA), accounting for 83.9%.(2) The infection rates of Staphylococcus aureus for the HAP patients in the five years were respectively 29.6%, 26.7%, 26.9%, 25.3%and 30.1%.There were no statistical differences in infection rates , when comparisons were made between the years (P>0.05).(3) Bacterial resistance analysis indicated that the patients with HAP-MRSA infection were completely sensitive to vancomycin and linezolid ( by 100%) , fairly sensitive to compound sulfamethoxazole and rifampicin ( by about 70%) and other antibiotics , such as beta lactams , macrolides and fluoroquinolones , was poorly sensitive ( by as low as less than 30%).Conclusion In HAP patients, Staphylococcus aureus was the main Gram positive pathogen , with MRSA infec-tion being the main case .Vancomycin and linezolid should be the first choice of drugs in clinical application of antibiotics for the treat -ment of HAP-MRSA infection.
