Effects of ambroxol hydrochloride combined with N-acetylcysteine on serum thymic stromal lymphopoietin and eosinophilic cationic protein in the patients with chronic obstructive pulmonary disease
10.3969/j.issn.1009-0754.2017.06.013
- VernacularTitle:盐酸氨溴索联合N-乙酰半胱氨酸对慢性阻塞性肺病患者血清胸腺基质淋巴生成素和嗜酸粒细胞阳离子蛋白的影响
- Author:
Haitao ZHANG
1
;
Yingming ZHANG
;
Caiying WANG
;
Shencun FANG
;
Bin XU
;
Dan LIU
Author Information
1. 南京大学医学院附属南京胸科医院九病区东
- Keywords:
Ambroxol hydrochloride;
N-acetylcysteine;
Chronic obstructive pulmonary disease;
Thymic stromal lymphopoie-tin;
Eosinophilic cationic protein
- From:
Journal of Navy Medicine
2017;38(6):513-516
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of ambroxol hydrochloride combined with N-acetylcysteine on serum thymic stromal lymphopoietin ( TSLP) and eosinophilic cationic protein ( ECP) in the treatment of the patients with chronic obstructive pulmo-nary disease ( COPD) .Methods One hundred and six patients who were diagnosed as COPD in acute stage and treated in the hospital from October 2013 to October 2016 were recruited as study subjects .The patients were randomly divided into 2 groups: the control group (n=51) and the observation group (n=55), and another 50 health examinees were selected as the healthy control group . Results Before treatment, forced expiratory volume in one second (FEV1)in the patients of the 2 chronic bronchitis groups accounted for a low proportion of the predicted value (P<0.05), and the levels of TSLP and ECP were relatively high (P<0.05).After treat-ment, FEV1 level increased (P<0.05), while the levels of TSLP and ECP decreased (P<0.05).As compared with that of the con-trol group, FEV1 level increased, but TSLP and ECP levels decreased significantly in the observation group (P<0.05).In course of treatment , no obvious adverse reactions were observed in the patients of the 2 groups .Total number of effective cases in the observation group was greater than that of the control group (P<0.05).Conclusion Ambroxol hydrochloride combined with N-acetylcysteine was safe and effective in the treatment of COPD , the mechanism of which might be associated with the indirect decrease of serum TSLP and ECP.
