Effects of small dose of rituximab combined with frozen plasma on serum cytokine level in the treatment of thrombocytopenia induced by Linezolid
10.3969/j.issn.1009-0754.2017.05.019
- VernacularTitle:小剂量美罗华联合冰冻血浆对利奈唑胺所致血小板减少症患者血清细胞因子水平的影响
- Author:
Wenjing LI
1
;
Zhiwei WANG
;
Yongli SUN
;
Tianhua ZHAO
;
Wenjin WANG
Author Information
1. 解放军白求恩国际和平医院血液科
- Keywords:
Rituximab;
Frozen plasma;
Linezolid;
Trombocytopenia
- From:
Journal of Navy Medicine
2017;38(5):442-444
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effects of small dose of rituximab combined with frozen plasma on thrombocytopenia in-duced by Linezolid, as well as on serum levels of IL-33, TNF-αand IFN-γ.Methods One hundred and four patients with thrombocy-topenia who sought medical care in the hospital were recruited as research objects , and another 52 normal examinees who had physical examination at the hospital at the same period were chosen as the healthy group .The patients in the study group were given small dose of rituximab combined with frozen plasma , while the patients in the control group received just small dose of rituximab .The levels of se-rum IL-33, TNF-αand IFN-γin in the 2 patient groups were respectively detected both before and after treatment , and those levels in the healthy group were measured as well .Results Before treatment, the serum IL-33, TNF-αand IFN-γlevels of the 2 patient groups were significantly higher than those of the healthy group (P<0.05), and no statistical differences could be seen in the serum levels of the 2 patient groups (P>0.05).After treatment, the serum IL-33, TNF-αand IFN-γlevels of the 2 patient groups were all obviously decreased, and the serum IL-33, TNF-αand IFN-γlevels of the study group were significantly lower than those of the control group (P<0.05).Conclusion Small dose of rituximab combined with frozen plasma in the treatment of thrombocytopenia could significantly reduce the serum levels of IL-33, TNF-αand IFN-γ, and the effects of the combined treatment with rituximab and frozen plasma were obviously superior to those with single treatment of rituximab .
