Clinical significance of platelet/lymphocyte ratio in the differentiation and severity determination of ulcerative colitis
10.3969/j.issn.1009-0754.2017.05.018
- VernacularTitle:血小板与淋巴细胞比值对溃疡性结肠炎鉴别诊断及其严重程度判定的临床意义分析
- Author:
Liling JING
1
;
Qian GAO
;
Zhengyu ZHOU
;
Jie MENG
;
Ying HE
;
Shanrong LIU
Author Information
1. 第二军医大学附属长海医院实验诊断科
- Keywords:
Platelet to lymphocyte ratio;
Ulcerative colitis;
Irritable bowel syndrome
- From:
Journal of Navy Medicine
2017;38(5):439-441,451
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate clinical significance of platelet/lymphocyte ratio ( PLR) in the differentiation and severity determination of ulcerative colitis .Methods One hundred and ninety-two patients who sought medical care from June 2009 to June 2016, in Changhai Hospital , were enrolled as study subjects , of whom 97 were patients with ulcerative colitis and 95 were patients with irritable bowel syndrome .Differences in PLR between the 2 groups were analyzed and the sensitivity and specificity of PLR in the diag-nosis of ulcerative colitis were also evaluated .Through the modified Mayo score system , the activity of ulcerative colitis was evaluated , and pathological spreading site was determined by colonoscopy , and the correlation between PLR and disease activity and pathological spreading site was evaluated .Results As compared with those of the control group with irritable bowel syndrome , the while blood cell counts, blood platelet counts , PLR, the erythrocyte sedimentation rate and the C-reaction protein of the patients with ulcerative colitis were significantly increased, and statistical significance could be noted when comparisons were made between them (P<0.05).Statis-tical significance could be found in PLR differences between the ulcerative colitis patients and irritable bowel syndrome patients .ROC a-nalysis indicated that sensitivity and specificity of the PLR biomarker were respectively 67%and 58%.PLR data for the patients with irritable bowel syndrome and those with light , moderate and severe ulcerative colitis were 123.73 ±60.47, 114.32 ±43.66, 160.19 ± 56.52 and 253.35 ±86.82 respectively.Results indicated that there was no statistical significance in the clinical data between irritable bowel syndrome and light ulcerative colitis (P=0.54).However, statistical significance could be noted in the data between irritable bowel syndrome and moderate/severe ulcerative colitis(P<0.05).Statistical significance could all be seen in the differences of the clinical data between light, moderate and severe ulcerative colitis (P<0.05).But there was no statistical difference in PLR between different pathological lesions in the patients with ulcerative colitis (P>0.05).Conclusion PLR has certain clinical value and signifi-cance in the identification and diagnosis of ulcerative colitis and irritable bowel syndrome , and at the same time , it could evaluate the degree of inflammation of ulcerative colitis .
