Clinical analysis of Xingnaojing injection combined with gastroenteric fluid replacement in the treatment of hyperosmolar nonketotic diabetic coma
10.3969/j.issn.1009-0754.2017.05.008
- VernacularTitle:醒脑静注射液联合胃肠内补液治疗糖尿病高渗性非酮症昏迷的疗效分析
- Author:
Daoming WEI
1
;
Xuehong ZHU
Author Information
1. 解放军第八五医院神经内分泌科
- Keywords:
Xingnaojing injection;
Gastroenteric fluid replacement;
Hyperosmolar nonketotic diabetic coma
- From:
Journal of Navy Medicine
2017;38(5):408-410,417
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical effect of Xingnaojing injection combined with gastroenteric fluid replacement in the treatment of hyperosmolar nonketotic diabetic coma ( HNDC) .Methods In accordance with different treatment methods , 150 HNDC patients who received medical care in the Neurological and Endocrinological Department of the hospital from April 2015 to April 2017 were divided into 3 groups, i.e.the conventional treatment group , the gastroenteric fluid replacement group and the Xingnaojing injection combined with gastroenteric fluid replacement group (or the combination group ), each consisting of 50 patients.Blood bio-chemical indexes and changes in plasma osmotic pressure were detected in the patients of the 3 groups, both before therapy and at hour 24 and hour 48 after therapy, and the therapeutic efficacy , rate of complications and mortality were also closely observed .Results To-tal effective rates of the gastroenteric fluid replacement group and the combination group were significantly higher than that of the con -ventional treatment group(P<0.01).As compared with that of the gastroenteric fluid replacement group , total effective rate of the combination group was also significantly higher(P<0.05).The levels of blood glucose, serum sodium, blood urea nitrogen and plasma osmotic pressure at hour 24 and hour 48 after treatment were all lower than those before treatment (P<0.01).The levels of blood glu-cose, serum sodium, blood urea nitrogen and plasma osmotic pressure in the patients of the gastroenteric fluid replacement group and the combination group were obviously lower than those of the conventional group at corresponding time points (P<0.05), and the a-bove-mentioned levels of the combination group were lower than those of the gastroenteric fluid replacement group (P<0.05).The rate of adverse reactions and mortality of the combination group were obviously lower than those of the gastroenteric fluid replacement group and the conventional group (P<0.05 or P<0.01).Conclusion The therapeutic efficacy of Xingnaojing injection combined with gas-troenteric fluid replacement in the treatment of hyperosmolar nonketotic diabetic coma is superior to those of the conventional fluid re -placement and single gastroenteric fluid replacement treatment , and this treatment method is simple and safe , which is worth further clinical extension .
