Changes in peripheral nerve damage area after firearm injury coupled with seawater immersion and personal experience of surgical treatment in rats
10.3969/j.issn.1009-0754.2017.05.001
- VernacularTitle:周围神经火器伤海水浸泡后大鼠神经损伤区域改变及手术处理体会
- Author:
Wenbin DING
1
;
Yanpeng ZHANG
;
Fei HUANG
;
Chuansen ZHANG
;
Jun YANG
;
Shaocheng ZHANG
Author Information
1. 海军军医大学附属长海医院创伤骨科
- Keywords:
Peripheral nerve;
Firearm injury;
Seawater immersion;
Degree of damage;
Surgical treatment
- From:
Journal of Navy Medicine
2017;38(5):385-388
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore pathological changes in peripheral nerve damage area after firearm injury coupled with sea -water immersion, so as to provide experimental evidence for clinical treatment of peripheral nerve firearm injuries .Methods One hun-dred and eighty SPF SD rats were randomly divided into 5 groups, i.e.the firearm sciatic nerve injury ( incomplete breaking injury ) coupled with seawater immersion rat model group ( or group A1 ) , the firearm sciatic nerve injury ( complete breaking injury ) coupled with seawater immersion rat model group (or group A2), the firearm sciatic nerve injury (incomplete breaking injury) rat model group (or group B1), the firearm sciatic nerve injury (complete breaking injury) rat model group (or group B2), and the sharply-severed sciatic nerve group (or group C).Observations were made on gross morphology and pathology following sciatic nerve injury .Results In group A1, nerve fibers were totally broken , capillaries beneath epineurium and perineurium were ruptured with multifocal hemor -rhage.In group A2, many nerve fibers were broken , with extensive hemorrhage beneath epineurium and perineurium and myelin was al -so ruptured.Microscopy showed that damages similar to those of group A1 and group A2 could be observed in group B1 and group B2. No significant nerve fiber rupture was observed in Group C , and epineurium and perineurium remained intact .With the extension of time, severe nerve tract edema was observed in group A1, group A2, group B1 and group B2, with the infiltration of large quantities of leukocytes.At all the time points,the degree of edema for group A1 and group A2 were obviously less severe than that of group B1 and group B2.Conclusion Nerve fiber damage was identical in group A1 and group A2, with severe inflammatory cell infiltration and less severe in the edema of epineurium and perineurium , as compared with those of group B1 and group B2.
