Clinical study on the prevention and treatment of peripheral neuropathy by compound troxerutin and porcine cerebroside injection after chemotherapy in tumor patients
10.3969/j.issn.1009-0754.2017.04.014
- VernacularTitle:复方曲肽注射液用于防治肿瘤患者化疗后周围神经毒性的临床研究
- Author:
Xiaoxue KOU
1
;
Yi HU
;
Liang PENG
;
Ruixia LINGHU
;
Junlan YANG
Author Information
1. 解放军总医院
- Keywords:
Compound troxerutin and porcine cerebroside injection;
Chemotherapy;
Peripheral neuropathy
- From:
Journal of Navy Medicine
2017;38(4):325-329
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the therapeutic effects of compound troxerutin and porcine cerebroside injection on the prevention and treatment of peripheral neuropathy in the patients after chemotherapy.Methods Clinical data of 58 tumor patients who received chemotherapy in the hospital from Aug.2015 to Feb.2016 were collected for the study,and the patients were randomly divided into two groups:the treatment group (n =28) and the blank control group (n =28).The treatment group received compound troxerutin and porcine cerebroside injection at a dosage of 10ml,once a day,for a succession of 3 days.Assessments of peripheral neuropathy were made by CTCAE standards and the obtained results were analyzed and compared in the patients of the 2 groups both before and after 2 cycles of chemotherapy.Results The patients all completed medical follow-ups.Before therapy,there were no statistical differences in the classification of peripheral neuropathy in the patients of the 2 groups (P ＞ 0.05).After therapy,statistical differences in the classification of peripheral neuropathy could be seen in the patients of the 2 groups(P ＞ 0.05).There were 15 patients with peripheral neuropathy before therapy.Analysis indicated that total effective rate of the treatment group was 75.00％,while that of the control treatment group was 0,and obvious statistical significance could be found when comparisons were made between the 2 groups (P ＜0.05).Conclusion Compound troxerutin and porcine cerebroside injection could produce good effect on the prevention and treatment of peripheral neuropathy induced by chemotherapy,and it was worth further clinical study by larger samples.
