Effect of different blood pressure modes on endothelial function and arteriosclerosis in patients with high blood pressure
10.3969/j.issn.1009-0754.2017.04.011
- VernacularTitle:不同血压模式对高血压病患者血管内皮功能及动脉硬化的影响
- Author:
Maodan FAN
1
;
Lei ZHOU
;
Yinan ZHANG
;
Yuetao CHEN
;
Shun ZHANG
Author Information
1. 南京军区杭州疗养院海勤疗养区
- Keywords:
Hypertension;
Arteriosclerosis;
Dynamic blood pressure monitoring;
Endothelial function
- From:
Journal of Navy Medicine
2017;38(4):313-316
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of different blood pressure modes on endothelial function and arteriosclerosis in patients with high blood pressure.Methods A retrospective analysis was made on such clinical data as dynamic blood pressure data,carotid-femoral pulse wave velocity (CFPwV) and the levels of thrombotic TM,nitric oxide (NO) and nitric oxide synthase (NOS) in 200 patients with high blood pressure and 100 normal people.In accordance with dynamic blood pressure level and drop rate of night blood pressure,the patients with high blood pressure were divided into the dipper type hypertension group and the non-dipper type hypertension group,each consisting of 100 patients.Then,data of dynamic blood pressure,CFPwV and the levels of TM、NO、NOS were compared between the 3 groups,and multiple-factor regression analysis was made on various dynamic blood pressure data and CFPwV.Results (1) When compared with those of the control group,dynamic blood pressure data,CFPwV and the levels of TM were increased,but the levels of NO and NOS were decreased in the dipper type hypertension group and the non-dipper type hypertension group (P ＜ 0.05).Night diastolic blood variation pressure(nDBVP),CFPwV and TM were increased,while the levels of NO、NOS were decreased (P ＜ 0.05).As compared with those of the dipper type hypertension group,nSBP,dDBP,24hSBVP,nSBVP,nDBVP,CFPwV and the level of TM were increased,while the levels of NO and NOS were decreased in the non-dipper type hypertension group (P ＜ 0.05).(2) Multiple-factor regression analysis revealed that 24hSBP,dSBP,nSBP,nDBP,nSBVP and nDBVP were independent influential factors for the increase of CFPwV.Conclusion (1) The damage to endothelial function in the non-dipper type hypertension group was severer than that in the dipper type hypertension group.Abnormal mode of hypertension could intensify endothelial lesion and facilitate atherosclerosis.(2) The research indicated that the level of dynamic blood pressure data,especially 24hSBP,dSBP,nSBP,nDBP,nSBVP and nDBVP were closely associated with atherosclerosis.For those non-dipper hypertension patients,it was of great clinical significance to control night blood pressure and correct abnormal blood pressure mode,in addition to the treatment for the decrease of blood pressure.
