Relationship between the level of lipoprotein(a) and carotid atherosclerotic plaques in patients with high blood pressure
10.3969/j.issn.1009-0754.2017.03.015
- VernacularTitle:高血压患者血清脂蛋白(a)浓度与颈动脉粥样硬化斑块的相关性研究
- Author:
Ying YANG
1
;
Shijie LIAN
;
Baohe ZHANG
;
Hongtao XU
Author Information
1. 海军总医院干部保健科
- Keywords:
Low-density lipoprotein cholesterol;
Lipoprotei(a);
Carotid atherosclerotic plaque
- From:
Journal of Navy Medicine
2017;38(3):229-231
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the serum level of lipoprotein(a) in high blood pressure patients with low density lipoprotein cholesterol (LDL-C) standards and its association with carotid atherosclerotic plaques.Methods Five hundred and thirty patients with history of hypertension for over 5 years were recruited for the study.They were stratified by depending on whether or not they reached the LDL-C standards.Then,by depending on whether there was presence of carotid plaques in each layer,they were divided into 4 groups:Group A with LDL-C standards and plaques,Group B with LDL-C standards but without plaques,Group C without LDLC standards but with plaques,Group D without LDL-C standards but without plaques.Close observations were made on the levels of Lp (a) in each groups.Results (1) The Lp (a) levels of the groups with LDL-C standards were lower than those of the groups without LDL-C standards.Statistical significance could be noticed when comparisons were made between them(P ＜ 0.01).(2) In the group with LDL-C standards,the Lp (a) level in the patients of Group A was higher than that in the patients of Group B,but there was no statistical significance when comparisons were made between them (P ＞ 0.05).In the group without LDL-C standards,the Lp (a) level in the patients of Group C was higher than that in the patients of Group D,with statistical significance (P ＜ 0.01).Conclusion For the patients with LDL-C level reaching the required standards at the admission,baseline level of Lp (a) seemed to have no obvious correlation with carotid atherosclerotic plaques.However,for the patients without LDL-C level reaching the required standards at the admission,elevated baseline LDL-C level might be a predicting factor in the formation of carotid atherosclerotic plaques.
