Development of laboratory animal model of serious traumatic brain injury and its clinical significance
10.3969/j.issn.1009-0754.2017.02.008
- VernacularTitle:重型颅脑损伤的动物实验模型制作及其临床意义
- Author:
Qi YING
1
;
Shoulong LU
;
Fenglin ZHANG
;
Xiaolong XU
;
Yin TANG
;
Yong JIAO
;
Quan WANG
;
Xiaoxi WANG
;
Xiaoli ZHANG
;
Ning LU
Author Information
1. 解放军第四一一医院
- Keywords:
Severe traumatic brain injury;
Trauma-inducing impact;
Clinical significance;
Open decompression;
Close decompression
- From:
Journal of Navy Medicine
2017;38(2):113-115,130
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish replicable animal model of serious traumatic brain injury (S-TBI) in rats.Methods An improved free fall apparatus was used to give impacts on the vault of skull of 80 anesthetized rats with a 50-200 g weight from a 20-50 cm height,the rats were observed for 4 hr to 12 days after impact,and brain was collected after anesthesia to make 652 pathological sections.Results The optimum impact force was determined as 10 000 g/cm.There was a marked correlation between pathological changes and clinical manifestation,which had a reference value to the diagnosis and treatment of S-TBI.A comparison between simulated clinical closed decompression and open decompression indicated that the latter was more favorable for the rehabilitation of brain trauma.Conclusion The optimum impact force was found in rats of severe traumatic brain injury through experiments;experimental animals were significantly correlative to clinical diagnosis and treatment;open decompression was more beneficial to brain rehabilitation.
