Hemostatic effect of endoscopic titanium-clip combined with drugs on non-variceal upper gastrointestinal bleeding and evaluation on stress and inflammation
10.3969/j.issn.1009-0754.2017.01.016
- VernacularTitle:内镜下钛夹联合药物治疗非静脉曲张性上消化道出血的止血效果及机体的应激和炎症程度评估
- Author:
Xianwen ZHANG
1
;
Jianqiang ZHU
;
Kaixiang FENG
Author Information
1. 绵阳市中心医院内镜室
- Keywords:
Non-variceal upper gastrointestinal bleeding;
Endoscopy;
Titanium-clip
- From:
Journal of Navy Medicine
2017;38(1):46-49
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the hemostatic effect of endoscopic titanium-clip combined with drugs on non-variceal upper gastrointestinal bleeding and evaluation on stress and inflammation .Methods Patients with non-variceal upper gastrointestinal bleeding admitted into the hospital from August 2012 to December 2014 were enrolled for the study .Those who received drug treatment were as-signed as the control group , and those who were given endoscopic titanium-clip combined with drugs were assigned as the observation group.After treatment, differences in hemostatic effect and levels of oxidative stress and inflammation-related factors were compared be-tween the 2 groups.Results Total blood loss of the observation group after treatment was less than that of the control group , and the rate of effective hemostasis and rehabilitation after endoscopic treatment were obviously higher than that of the control group ( P<0. 05).Serum VitE level of the observation group after treatment was higher than that of the control group , and AOPP, malondialdehyde (MDA), Cortisol(Cor), growth hormone(GH), antidiuretic normone(ADH) and blood sugar(BS) levels were lower than those of the control group (P<0.05).Three and 12 hours after treatment, serum C-reative protein(CRP), interleukin-1β(IL-1β), interleukin-6 (IL-6) and tumor necrosis factor-α(TNF-α) values of the observation group were lower than those of the control group , however, IL-10 value was higher than that of the control group (P<0.05).Conclusion Endoscopic titanium-clip combined with drugs in the treatment of patients with non-variceal upper gastrointestinal bleeding could effectively enhance hemostatic effect and optimize systemic oxidative stress and inflammation , which was of positive clinical significance .
