Inhibition of Na+/H - exchanger 1 alleviates burn-induced multiple organ injury in rats
10.3969/j.issn.1009-0754.2017.01.006
- VernacularTitle:钠氢交换蛋白1抑制剂对严重烧伤后多脏器损伤大鼠的保护作用研究
- Author:
Wenpeng LI
1
;
Gaoyang ZHAO
;
Xuekang YANG
;
Teng MA
Author Information
1. 第四军医大学西京医院烧伤与皮肤外科
- Keywords:
Burns;
Multiple organ injury;
Na+/H-exchanger 1;
Inflammation;
Rats
- From:
Journal of Navy Medicine
2017;38(1):14-17
- CountryChina
- Language:Chinese
-
Abstract:
Objective Severe burns initiate inflammatory response characterized by the upregulation of proinflammatory cytokine , which contributes to multiple organ injury.Na+/H-exchanger 1 (NHE1) plays a significant role in several inflammatory processes.This study was designed to investigate the role of NHE1in burn-induced inflammation and multiple organ injury.Methods Rats were subjected to a 30%total body surface area full-thickness burn.Cariporide was used to assess the function of NHE1in burn-induced multiple organ injury by biochemical parameters, histologic changes, and inflammatory cytokine production.Results We found that NHE1expression was signifi-cantly increased after burn injury.Inhibition of NHE1by cariporide attenuated burn-induced edema and tissue injury in heart, lung, kidney, and small intestine.Cariporide also inhibited plasma levels of tumor necrosis factor alpha (TNF-α), interleukin 6 (IL-6), and myeloperoxi-dase activity (MPO).Conclusion These results indicate that NHE1inhibition prevents burn-induced multiple organ injury.The salutary effects afforded by NHE1inhibition, at least in part, are mediated by attenuating systemic inflammatory response.
