Therapeutic effects of estradiol valerate through vaginal drug delivery in female infertility due to thin endometrium
10.3969/j.issn.1009-0754.2016.06.019
- VernacularTitle:阴道摄入戊酸雌二醇在薄型子宫内膜不育症中的临床疗效分析
- Author:
Haiya YAN
1
;
Xiaorong CAO
;
Songyun XIA
Author Information
1. 宝鸡市妇幼保健院妇科
- Keywords:
Estradiol valerate;
Vaginal drug delivery;
Thin endometrium;
Infertility;
Pregnancy
- From:
Journal of Navy Medicine
2016;37(6):548-550
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate and evaluate the therapeutic effects of estradiol valerate through vaginal drug delivery in the treatment of female infertility due to thin endometrium .Methods Close observation was made on the 256 female infertility patients due to thin endometrium.With the knowledge and consent of the patients , the patients were divided into 2 groups, the observation group and the control group .The control group received oral estradiol valerate , while the observation group was treated with estradiol valerate through vaginal drug delivery .Changes in the thickness and blood flow improvement of endometrium in ovulation days were closely ob -served in the patients of the 2 group.Then, one-year follow-up was made on the pregnancy rate and abortion rate in the patients of the 2 groups.Results The endometrial thickness in the observation group was significantly increased , as compared with that of the control group, with statistical significance (P<0.001).Following treatment, endometrial blood flow in the observation group was obviously improved, when compared with that of the control group , also with statistical significance (P<0.05).One year after treatment, the pregnancy rate of the observation group was significantly higher than that of the control group , and statistical significance could be seen when comparisons were made between the 2 groups (P<0.01).At the same time, the abortion rate of the observation group was obvi-ously lower than that of the control group (P<0.05).Conclusion Estradiol valerate through vaginal delivery in the treatment of female infertility due to thin endometrium could significantly improve the endometrial thickness and blood flow in ovulation days and increase pregnancy rate .The therapeutic effects of vaginal drug delivery were significantly superior to oral administration of estradiol valerate .
