Association between the levels of heat shock protein 27 and 70 and pulmonary function and life quality in the patients with chronic obstructive pulmonary disease
10.3969/j.issn.1009-0754.2016.06.008
- VernacularTitle:慢性阻塞性肺疾病患者血清 HSP27和 HSP70与肺功能及生活质量的相关性
- Author:
Yunlong LIU
1
;
Yong LUO
;
Guisheng DENG
Author Information
1. 上海交通大学医学院附属新华医院崇明分院呼吸内科
- Keywords:
Chronic obstructive pulmonary disease;
Heat shock protein 27;
Heat shock protein 70;
Lung function;
Life quality index
- From:
Journal of Navy Medicine
2016;37(6):505-508
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the association between the levels of heat shock protein 27 (HSP27) and 70 (HSP70) and pulmonary function and life quality in the patients with chronic obstructive pulmonary disease ( COPD) .Methods Forty-five patients with acute exacerbation of COPD admitted for treatment in our hospital from February 2015 to April 2016 were enrolled for the study , and were divided into the observation group (n=45) and the control group (50 healthy subjects) .Serum samples were collected from the patients of the 2 groups.The levels of serum HSP27 and HSP70 were detected by ELISA .The life quality of the COPD patients was evaluated by using the CAT scale , and the association between the levels of HSP 27 and HSP70 and pulmonary function and life quality was discussed in the paper .Results As compared with those of the control group , the expression levels of HSP 27 and HSP70 in the pa-tients of the observation group were significantly increased [(3 590.25 ±503.42) ng/L vs (1 974.08 ±527.38) ng/L] versus [(331.82 ±18.61)ng/L vs(162.73 ±51.52)ng/L] (P<0.01).Statistical significance was shown when comparisons were made be-
tween them(P<0.01).Spearman sequence analysis indicated that serum levels of HSP 27 and HSP70 were negatively correlated with FEV l%(r=-0.674, -0.569, P<0.05).CAT scores of the observation group were negatively correlated with FEV l% ( r=-0.43, P<0.05), and the serum levels of HSP27 and HSP70 in the observation group were positively correlated with CAT scores (r=0.622,0.53, P<0.05).Conclusion The CAT scale could effectively evaluate the life quality of COPD patients .HSP27 and HSP70 were involved in the process of inflammatory reaction and oxidative stress of COPD , which was of diagnostic value and clinical significance in the treatment of patients with acute exacerbation of COPD .
