Comparison of laparoscopic hepatectomy with open hepatectomy in the treatment of primary hepatocarcinoma during perioperative period: a meta-analysis
10.3969/j.issn.1009-0754.2016.05.020
- VernacularTitle:腹腔镜肝切除与开腹肝切除治疗原发性肝癌安全性及疗效的Meta分析
- Author:
Chang XU
1
;
Xiangji LUO
;
Mengchao WU
;
Xiaoqing JIANG
Author Information
1. 第二军医大学附属东方肝胆外科医院胆道三科
- Keywords:
Laparoscopy;
Primary hepatocarcinoma;
Hepatectomy;
Meta-analysis
- From:
Journal of Navy Medicine
2016;37(5):439-442,448
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate surgical safety and effectiveness of laparoscopic hepatectomy ( LH) and traditional open hepatectomy ( OH) in the treatment of primary hepatocarcinoma during perioperative period by meta-analysis.Methods The Pubmed, EMBASE, Cochrane Library and Medline database were retrieved for randomized controlled studies and retrospective controlled studies on the comparison of laparoscopic hepatectomy and traditional open hepatectomy for hepatocellular carcinoma published from the incep-tion to April 2016, and extended information retrieval was performed in accordance with the retrieved documents.Meta-analysis was performed by using Cochrane Review Manager Software (Version 5.3).Indicators for analysis included surgical blood loss, surgical time, postoperative complications, perioperative mortality, as well as length of hospital stay.Results A total of 10 studies conforming to the required standards were included in the study, involving a total of 1113 patients.Meta-analysis indicated that no significant differences could be seen in perioperative mortality, when comparisons were made between LH and OH ( OR=0.67, 95%CI=0.28~1.62, P=0.38).However, as compared with OH, LH had a significant advantage in surgical time (MD=-16.65, 95% CI=-26.59~-6.71, P=0.001), surgical blood loss (MD=-171.83, 95%CI=-305.50~-38.16, P=0.01), total postopera-tive complications (OR=0.47, 95%CI=0.34~0.65, P<0.05), and length of hospital stay (MD=-3.80, 95% CI=-5.63~-1.97, P<0.05).Conclusion Meta-analysis revealed that LH was equivalent to OH in surgical safety in the treatment of primary hep-atocarcinoma, however, it was superior to OH in surgical time, surgical blood loss, perioperative mortality and length of hospital stay.
