Correlation analysis between homocysteine level and arteriosclerosis in high blood pressure patients in routine medical examination
10.3969/j.issn.1009-0754.2016.05.012
- VernacularTitle:高血压病患者血浆同型半胱氨酸水平与动脉硬化的相关性分析
- Author:
Lei ZHOU
1
;
Maodan FAN
;
Min YANG
;
Guodong SUN
Author Information
1. 南京军区杭州疗养院海勤疗养区
- Keywords:
High blood pressure;
Homocysteine;
Arteriosclerosis;
Pulse wave velocity
- From:
Journal of Navy Medicine
2016;37(5):411-414
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the correlation between homocysteine (Hcy) level and arteriosclerosis in hypertension pa-tients.Methods Four hundred and twenty hypertension patients (assigned as the experimental group) and 192 healthy examinees (as-signed as the control group) were recruited for the study, and the hypertension patients were further subdivided into the normal Hcy group, the slightly higher Hcy group and the obviously high Hcy group, in accordance with the plasma levels of Hcy.Carotid-femoral pulse wave velocity ( CFPwV) was measured by automatic pulse wave velocity detector and was used as an arteriosclerosis indicator. Blood pressure parameters, Hcy levels, CFPwV levels were compared between the 4 groups and the incidence of atherosclerosis for each group were calculated accordingly.Then, Pearson correlation analysis and multiple regression analysis were performed in all the associ-ated factors of hypertension with CFPwV.Results (1) As compared with those of the control group, the levels of systolic blood pres-sure ( SBP) , diastolic blood pressure ( DBP) , mean arterial blood pressure ( MAP) , pulse pressure ( PP) , Hcy and CFPwV increased in all the experimental groups (P<0.05).As compared with those of the Hcy normal group, the levels of SBP, DBP, MAP, PP, Hcy and CFPwV increased in the slightly higher Hcy group and the obviously high Hcy group (P<0.05).And as compared with those of the slightly higher Hcy group, the levels of SBP, Hcy and CFPwV in the obviously high Hcy group all elevated significantly ( P<0.05).(2) The incidence of atherosclerosis in the slightly higher Hcy group and the obviously high Hcy group was higher than those of the normal Hcy group (P<0.05).(3) Pearson correlation analysis revealed that CFPwV was positively correlated with age, SBP, DBP, PP, MAP and Hcy.Results of multiple linear regression analysis indicated that Hcy, SBP and PP were independent influential factors of CFPwV.Conclusion Hcy, SBP and PP were independent influential factors of CFPwV.High Hcy level and hypertension were synergistic, and high Hcy could increase the risk of atherosclerosis due to hypertension, indicating that hypertension and high Hcy level were all involved in the occurrence and development of atherosclerosis.
