Effect of oxaliplatin combined with S-1 chemotherapy on the resection of advanced gastric cancer
10.3969/j.issn.1009-0754.2016.04.014
- VernacularTitle:奥沙利铂联合替吉奥化疗对进展期胃癌手术切除的影响
- Author:
Guoquan HUANG
1
;
Quanfeng WU
;
Jianhua SUN
;
Bitao ZHANG
Author Information
1. 湖北省恩施土家族苗族自治州中心医院胃肠外科
- Keywords:
Oxaliplatin;
S-1;
Advanced gastric cancer;
Resection rate
- From:
Journal of Navy Medicine
2016;37(4):326-328
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of oxaliplatin combined with S-1 ( SOX ) chemotherapy on the resection of ad-vanced gastric cancer.Methods Twenty patients with advanced gastric cancer, who first underwent oxaliplatin combined with S-1 chemotherapy and then received surgery, were recruited as the combined treatment group, while another 20 surgical patients with ad-vanced gastric cancer who did not have chemotherapy were assigned as the control group.The surgical resection rate, the number of postoperative lymphatic node metastasis and the average length of stay in the hospital were compared between the patients of the 2 groups.Results The surgical resection rate in the 20 patients of the combined treatment group was as high as 95%, while that of the control group was just 70%.Statistical significance could be found, when comparisons were made between them(P<0.05).There were statistical differences in the number of postoperative lymphatic node metastasis and the average length of stay, when comparisons were made between the combined treatment group and the control group(P<0.05).Conclusion The application of combined chemo-therapy with oxaliplatin and S-1 before surgery could achieve better clinical therapeutic effects.
