Clinical effects of quercetin in the treatment of 30 patients with high-risk type HPV positive CIN
10.3969/j.issn.1009-0754.2016.02.018
- VernacularTitle:槲皮素治疗高危型人乳头瘤病毒阳性的宫颈上皮内瘤变患者30例疗效观察
- Author:
Yanhong FENG
1
;
Bingjie ZHANG
;
Shuai SHI
;
Man LIANG
;
Qin LI
Author Information
1. 陕西中医药大学第二附属医院
- Keywords:
Quercetin;
Human papillomavirus;
Cervical intraepithelial neoplasia;
Comparative study
- From:
Journal of Navy Medicine
2016;37(2):157-159
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical effects of quercetin in the treatment of patients with high-risk type human papillomavirus ( HPV) positive cervical intraepithelial neoplasia ( CIN) .Methods Ninety patients with HPV positive CIN hospitalized in the Outpatient Department of Gynecology, Second Affiliated Hospital, Shanxi Chinese Pharmacological University, from September 2012 to December 2015 were selected for the study.The patients were equally divided into 3 groups:the treatment group, the positive control group and the blank control group.The treatment group received medication of 3 g quercetin by the way of vagina.The positive control group was given 6 g Opin ( plug) also by the way of vagina, and the blank control group had routine cleansing of vagina.The pa-tients of the 3 groups received treatment once every other day, for a succession of 2 weeks, with 2 weeks as a treatment course, and with a total of 3 treatment courses.Three months later, the patients were reexamined on HPV and fluid-based cells, and had pathological ex-amination as well.Results Twenty-two patients with high-risk type HPV in the treatment group turned negative, with the negative-turn-ing rate of 73.3%, while 21 patients with high-risk type HPV in the positive control group turned negative, with the negative-turning rate of 70.0%, and 17 patients in the blank control group turned negative, with the negative-turning rate of 33.3%.Following treat-ment, the negative-turning rates of the treatment group and the positive control group were higher than that of the negative control group (P<0.05).With regard to fluid-based cells, 28 patients in the treatment group turned negative, with the negative-turning rate of 93. 3%.On the other hand, there were 18 patients in the positive control group that turned negative, with the negative-turning rate of 60. 0%; and there were only 10 patients in the blank control group that turned negative, with the negative-turning rate of 33.3%.The neg-ative-turning rate of the treatment group was significantly higher than those of the positive control group and the blank control group( P<0.05).With regard to pathological detection results, 21 patients in the treatment group turned negative, with the negative-turning rate of 70.0%, 19 patients in the positive control group turned negative, with the negative-turning rate of 63.3%, while in the blank control group, there were only 16 patients that turned negative, with the negative-turning rate of 53.3%.The negative-turning rates of the treat-ment group and the positive control group after treatment were higher than that of the blank control group, and statistical significance could be seen when comparisons were made between them(P<0.05).Conclusion Quercetin could produce significant therapeutic effects on the CIN patients infected with HPV, and it also turned out to have certain anti-inflammatory effect.
