Effects of dexmedetomidine combined with butorphanol on the analgesia of the patients after gynecological laparoscopic surgery
10.3969/j.issn.1009-0754.2016.02.010
- VernacularTitle:右美托咪定复合布托啡诺对妇科腹腔镜手术患者术后镇痛的效果观察
- Author:
Chengyan DONG
1
;
Jiangtao CHANG
;
Liying ZHANG
;
Haiying ZOU
;
Jiahai MA
Author Information
1. 青岛大学医学院附属烟台毓璜顶医院麻醉科
- Keywords:
Dexmedetomidine;
Butorphanol;
Patient-controlled intravenous analgesia;
Gynecological laparoscopic surgery
- From:
Journal of Navy Medicine
2016;37(2):125-128
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the safety and efficacy of dexmedetomidine combined with butorphanol in patients with in-travenous analgesia after gynecological laparoscopic surgery.Methods Eighty patients who underwent gynecological laparoscopic sur-gery by general anesthesia were randomly divided into 2 groups, each consisting of 40 patients.With the anesthesic induction of dexme-detomidine and butorphanol, the patients in the dexmedetomidine combined with butorphanol group ( or the DB group) further received 0.5μg/kg dexmedetomidine by intravenous pumping, while the patients in the control group received the same volume of normal saline. Fifteen minutes before the end of surgery, the patients in both groups received 1.0 mg butorphanol.Patient-controlled intravenous anal-gesia(PCIA)was implemented after surgery.The patients in the control group received 0.125 mg/kg butorphanol with the highest dos-age not exceeding 10 mg, while the patients in the DB group were given butorphanol plus 0.1 μg/kg.h dexmedetomidine, with the highest dosage not exceeding 300μg.VAS and analgesia scores were observed at h 1, 2, 6,12 and 24 after surgery.The total number of button pressing of PCIA within 24 hours was observed, the number of supplementary analgesic agents was recorded, and adverse drug reactions and total rate of patient satisfaction were evaluated statistically.Results VAS scores at rest and exercise at h 1, 2, 6, 12 and 24 for the patients of the DB group were all significantly lower than those of the control group after surgery, with statistical significance ( P<0.05) .The total number of button pressing of PCIA for the patients of the DB group was less than that of the control group, and butorphanol consumption of the DB group was also significantly lower, also with statistical significance (P<0.05) .As compared with the control group, the rates of nausea and vomiting, dizziness for the patients of the DB group were all significantly lower, and statistical significance could be noted when comparisons were made between the 2 groups (P<0.05).Total rate of satisfaction with analgesia was considerably high after surgery, with statistical significance (P<0.05).Adverse drug reactions, such as bradycardia and respiratory inhibition did not occur in the patients of both groups.Conclusion Dexmedetomidine could enhance the analgesic effect of butorphanol after gynecological laparoscopic surgery, reduce the consumption of the butorphanol and decrease adverse drug reactions, and most im-portantly increase the rate of patients′satisfaction.
