Observation on the effects of horizontal linear acceleration on oculus in rabbits
10.3969/j.issn.1009-0754.2016.02.001
- VernacularTitle:水平直线加速度对兔眼影响的实验观察
- Author:
Kejie MAO
1
;
Xiujun PENG
;
Liqun CAO
Author Information
1. 安徽医科大学海军总医院临床学院
- Keywords:
Acceleration;
Ocular injury;
Rabbit
- From:
Journal of Navy Medicine
2016;37(2):97-99,128
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of horizontal linear acceleration on oculus in rabbits.Methods Four levels of horizontal linear acceleration intensity, i.e.the single-day mild load group, the single-day high load group, the 14-day mild load group and the 14-day high load group, were set for the experiment.The New Zealand white rabbits were used for the experiment with the horizontal linear acceleration simulator.Changes in the eyes of the experimental animals were detected by slit-lamp microscope, color ocular fundus photography, optical coherence tomography and pattern visual evoked potential.Comparisons were made in the changes induced by different loads between the groups.Results Morphological and electrophysiological detections revealed that there was no significant abnormity in the animals of the single-day mild load group, the single-day high load group and the 14-day mild load group. No significant morphological changes could be seen in the 14-day high load group.However, P-VEP indicated that the latent period of N75, P100 and N145 waves were prolonged at hour 1 and day 1 with the acceleration load [(81.63 ±5.36)ms, P<0.05;(117.38 ± 6.271) ms, P<0.05;(142.42 ±7.91)ms, P<0.05)].The amplitudes of P100 and N145 waves were decreased an hour after ac-celeration [(3.98 ±1.04)μV, P<0.05;(-3.53 ±1.045) μV, P<0.05)].The changes in all the amplitudes returned to normal 7 days after acceleration load [(71.91 ±9.30) ms, P<0.05; (97.63 ±8.76) ms, P<0.05; (119.17 ±8.80) ms, P<0.05;(5.14 ±1.28) μV, P<0.05)], with the exception of N145 wave which returned to normal 1 day after acceleration load [(-5.44 ± 1.82)μV, P<0.05)].Conclusion The effects of horizontal linear acceleration on oculus in rabbits displayed chronically reversible functional changes, furthermore, certain intensity was required to induce the changes.
