Clinical study on non-invasive positive pressure ventilation combined with naloxone in the treatment of acute exacerbation of chronic obstructive pulmonary disease complicated with type Ⅱ respiratory failure
10.3969/j.issn.1009-0754.2016.01.011
- VernacularTitle:无创正压通气联合纳洛酮治疗慢性阻塞性肺疾病急性加重期并发Ⅱ型呼吸衰竭的临床研究
- Author:
Guisheng DENG
1
;
Yong LUO
Author Information
1. 上海交通大学附属新华医院崇明分院呼吸内科
- Keywords:
Non-invasive positive pressure ventilation;
Naloxone;
Chronic obstructive pulmonary disease;
Respiratory failure
- From:
Journal of Navy Medicine
2016;37(1):30-31,46
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the curative effect of non-invasive positive pressure ventilation combined with naloxone on acute exacerbation of chronic obstructive pulmonary disease ( COPD) complicated with type II respiratory failure .Methods The pa-tients in the treatment group were additionally given naloxone intravenously on the basis of conventional treatment combined with the non-invasive positive pressure ventilation , while the patients in the control group were administered with non-invasive positive pressure ventilation in addition to conventional treatment .Then, changes in blood gas indicators , ventilation time and duration of hospitalization before and after treatment were observed , and analyses were made between the 2 groups.Results After treatment, the blood gas indi-cators of the treatment group were superior to those of the control group (P<0.05).The average ventilation time of the treatment group was(5.6 ±2.0)days, while that of the control group was(7.1 ±3.0)days;the length of hospitalization for treatment group was (10.8 ±2.5) days and that for the control group was (13.2 ±3.0)days respectively.Statistical significance could be seen , when comparisons were made between the 2 groups(P<0.05).Conclusion The curative effect of non-invasive positive pressure ventilation plus naloxone was confirmative in the treatment of acute exacerbation of chronic obstructive pulmonary disease complicated with type II respiratory fail -ure, and it could significantly shorten ventilation time and hospital stay .
