Analysis on the curative effects of different respiratory stimulants combined with non-invasive positive pressure ventilation in the treatment of chronic obstructive pulmonary disease with respiratory failure
10.3969/j.issn.1009-0754.2015.06.018
- VernacularTitle:不同呼吸兴奋剂联合无创正压通气治疗慢性阻塞性肺病合并呼吸衰竭的临床疗效
- Author:
Xi TAN
1
;
Zongan LIANG
Author Information
1. 峨眉山市人民医院呼吸内科
- Keywords:
Chronic obstructive pulmonary disease;
Respiratory failure;
Nikethamide;
Multiple Shaple
- From:
Journal of Navy Medicine
2015;(6):523-526
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study clinical effects of different respiratory stimulants combined with non-invasive positive pressure ventilation in the treatment of chronic obstructive pulmonary disease ( COPD) with respiratory failure .Methods Eighty cases of COPD complicated with respiratory failure were randomly divided into group A and B , each consisting of 40 cases.The patients of group A were given BiPAP positive pressure ventilation combined with nikethamide , while the patients of group B received BiPAP positive pres-sure ventilation combined with multiple Shaple therapy .Then, blood gas indicators , respiratory data , prognosis and adverse reactions were compared between the groups .Results Following treatment , the partial pressure of oxygen in the patients of group B was signifi-cantly higher than that of group A, and the partial pressure of carbon dioxide was lower than that of group A (P<0.01).The respirato-ry rate and minute ventilation of the patients in Group B were significantly higher than those of the patients in group A (P<0.01).The intubation rate of the patients in group B was higher than that of the patients in group A (P<0.01).There was no statistical signifi-cance in the rate of mortality, when comparisons were made between the 2 groups (P>0.05).Statistical differences could neither be seen in adverse drug reactions, when comparisons were made between the 2 groups(P>0.05).Conclusion Multiple Shaple combined with BiPAP positive pressure ventilation could achieve better clinical effects on COPD with respiratory failure , better safety and reliabili-ty, and it was worth further clinical extension .
