Relationship between carotid intima-media thickness and plasma homocysteine in type 2 diabetic patients
10.3969/j.issn.1009-0754.2015.05.019
- VernacularTitle:2 型糖尿病患者颈动脉内膜中层厚度与血同型半胱氨酸水平的关系
- Author:
Xiaoqiang WEI
1
;
Zheng ZHANG
;
Ruoyu SHEN
;
Wei ZHANG
;
Erli XU
Author Information
1. 解放军第四一一医院
- Keywords:
Homocysteine;
Type 2 diabetes mellitus;
Vascular pathologic change
- From:
Journal of Navy Medicine
2015;36(5):434-437
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the relationship between carotid intima-media thickness ( MT) and plasma homocysteine ( Hcy) in type 2 diabetic patients.Methods Related indexes, such as body mass, blood pressure, blood lipid and blood sugar were evaluated in 127 patients with type 2 diabetes.At the same time, plasma homocysteine and carotid intima-media thickness were also measured.The obtained results were compared with those of the 103 controlled cases.After treatment, all the data detected during med-ical follow-ups were compared with those before treatment.Results (1) Before treatment, the triglyceride and Hcy levels of the type 2 diabetic patients were significantly higher than those of the control group.The elevated Hcy level in the patients with type 2 diabetes was 32.3%(41/127), which was obviously higher than 9.7%(10/103)of the control group.In the type 2 diabetic patients with high Hcy, MT was also higher than that of the patients with normal Hcy.(2) Following treatment, no significant reduction in carotid MT was seen in type 2 diabetic patients, and carotid MT in the patients with high Hcy was still higher than that of the patients with normal Hcy.Step-wise multiple regression analysis indicated that plasma Hcy concentration was a related independent factor influencing carotid MT of the type 2 diabetic patients.Conclusion Our study indicated that hyperhomosysteinemia might be one of the risk factors associated with early atherosclerosis in type 2 diabetic patients.
