Research on the effect of rutaecarpine-hydroxypropyl-β-cyclodextrins on enhanced solubility of rutaecarpine

VernacularTitle:羟丙基-β-环糊精对吴茱萸次碱的增溶作用研究
Author: Huihui TANG ¹ ; Zhen DU ; Qingyu CAI
Author Information

1. 海军总医院药剂科
Keywords: Rutaecarpine; Hydroxypropyl-β-cyclodextrins; Inclusion; Solubility
From: Journal of Navy Medicine 2015;(4):308-310,317
CountryChina
Language:Chinese
Abstract: Objective To improve the water solubility and bioavailability of rutaecarpine by using inclusion compound of hydroxypropyl-β-cyclodextrins and widening the application of rutaecarpine.Methods The inclusion compound of rutaecarpine-hydroxypropyl-β-cyclodextrins was prepared by using ultrasonic method.Then,powder X-ray diffraction,differential scanning calorime-try and infrared spectroscopy were used to identify and characterize the compound.High performance liquid chromatography (HPLC) was used to detect the solubility of the inclusion compound.Results Rutaecarpine and hydroxypropyl-β-cyclodextrins formed the inclu-sion compound,and the solubility of the inclusion compound was 90.40 mg/L,following formation of the compound.Conclusion Hydroxypropyl-β-cyclodextrins seemed to have good effect on the water solubility of rutaecarpine.The solubility of rutaecarpine was greatly increased through the formation of the inclusion compound.Consequently,it provided good evidence for further basic theoretic research in the development and application of rutaecarpine.