Therapeutic effects of radio frequency ablation on dysfunctional uterine bleeding and analysis of its adverse reactions
10.3969/j.issn.1009-0754.2015.03.011
- VernacularTitle:射频治疗功能失调性子宫出血的临床疗效和不良反应分析
- Author:
Liangtu DAI
1
;
Hua ZHANG
;
Lei WU
Author Information
1. 解放军第四一一医院妇产科
- Keywords:
Radio frequency ablation;
Menoxenia;
Endometrium;
Mifepristone;
Adverse reactions
- From:
Journal of Navy Medicine
2015;(3):224-226,232
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate therapeutic effects of radio frequency ablation ( RFCA) on dysfunctional uterine bleed-ing ( DUB) and analysis of its adverse reactions.Methods In accordance with different methods of treatment, 2 017 cases of dysfunc-tional uterine bleeding patients confirmed and diagnosed by dilatation and curettage were randomly divided into 3 groups: the RFCA group, the mifepristone group and the control group.The RFCA group (1 937 cases) received radio frequency ablation at a power rate of 30-35 W, the mifepristone group (40 cases) was continually given small doses of mifepristone orally, intravenous infusion and he-mostasis, and the control group (40 cases) received intravenous infusion, hemostasis and highly effective progestogen, as deemed nec-essary.The levels of hemoglobin ( Hgb) , the sizes of wombs and the levels of ovary hormone in the patients of the 3 groups were detec-ted periodically, and they all had medical follow-ups for observation of adverse reactions.Results After treatment, improvement could be seen in menorrhagia and anemia for the RFCA group and mifepristone group, but without statistical differences (P>0.05).In the mifepristone group, the mean levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), 17-esradiol (E2), progester-one ( P) were decreased in varying degrees following treatment, with Ez and P decreased more prominently, as compared with those be-fore medication (P<0.01), while the mean levels of FSH, LH, E2 and P did not fluctuate markedly for the RFCA group, and no sta-tistical significance could be seen, when comparisons were made between pre-treatment and post-treatment (P>0.05) .Main adverse reactions after treatment in the RFCA group were artificial abortion syndromes (212 cases), vaginal discharge (115 cases) and low fe-ver (83 cases)(<38℃).Main adverse reactions in the mifepristone group 3 months after drug withdrawal were irregular colporrhagia (4 cases) and insignificant changes in menstrual flow (2 cases).After 6 months, there was recurrence in 12 cases, which failed to re-spond to the original treatment, and as a result, other treatment had to be used instead.Conclusion The RFCA group could overcome
the deficiency of mifepristone and was a simpler, safer, more effective and less invasive treatment method.
