Clinical effects of BiPAP combined with tiotropium bromide in the treatment of chronic obstructive pulmonary disease with acute exacerbation
10.3969/j.issn.1009-0754.2015.01.010
- VernacularTitle:双水平气道正压通气联合噻托溴铵对慢性阻塞性肺病急性加重期的疗效观察
- Author:
Hongxia ZHAO
1
;
Shilin XU
;
Anshan ZHUO
;
Yushu CAO
;
Wanning TONG
Author Information
1. 解放军第四一一医院呼吸内科
- Keywords:
Bi-level positive airway pressure;
Tiotropium bromide;
Chronic obstructive pulmonary disease;
Acute exacerba-tion
- From:
Journal of Navy Medicine
2015;(1):24-27
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical effects of bi-level positive airway pressure ( BiPAP) combined with tiotropium bromide in the treatment of chronic obstructive pulmonary disease ( AECOPD) with acute exacerbation .Methods Sixty cases of AECO-PD with acute exacerbation were randomly divided into group A and group B , each consisting of 30 cases, and clinical analyses were made on them .The patients in both groups were given routine treatment , including oxygen breathing , spasmolysis , expectoration , anti-infection and BiPAP.At the same time, the patients in group B were administered with the above treatment couple with BiPAP inhala-tion agent, with a dosage of 18μg, once a day.Symptoms, pulmonary functions and blood-gas analysis were performed to see the effects and adverse reactions , and hospitalization days were also recorded accordingly .Results Total effective rate for group A was 73.33%, while the rate for group B was 93.33%, and statistical differences could be seen , when comparisons were made between them ( P<0.05 ) .Following treatment , symptom scores , pulmonary functions and results of blood gas analysis in the patients of both groups signif -icantly improved, as compared before treatment (P<0.05).The conditions of the patients in group B were obviously superior to those of the patients in group A, with statistical significance (P<0.05).For the average length of stay at the hospital , the patients in group B were obviously superior to those of the patients in group A (P<0.05).The incidence of adverse reactions for the patients in group B was low, with minor symptoms.Conclusion The effects of BiPAP combined with tiotropium bromide in the treatment of chronic ob-structive pulmonary disease with acute exacerbation were obviously superior to that by simple BiPAP therapy .Furthermore, the former was safer and more effective , which was worth further clinical extension .
