Effects of vacuum-assisted closure on the healing of radioactive ulcer in rabbits
10.3969/j.issn.1009-0754.2015.01.008
- VernacularTitle:封闭负压引流对兔放射性溃疡创面愈合的影响
- Author:
Zhenyu GONG
1
;
Xiaoyan FENG
;
Ruihua XIONG
;
Qiu ZHAN
;
Xiaolong LI
Author Information
1. 541002 广西 桂林，解放军第一八一医院烧伤整形科; 541002 广西 桂林，解放军第一八一医院烧创伤早期损害与组织修复研究实验室
- Keywords:
Vacuum-assisted closure;
Radioactive ulcer;
Tissue structure;
Matrix metalloproteinase;
Tissue inhibitor of met-alloproteinase;
Cytokine
- From:
Journal of Navy Medicine
2015;(1):16-19
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of vacuum-assisted closure ( VAC) on the healing of the radioactive ulcer in rabbits.Methods The rabbit radioactive ulcer model was established , and the animals were divided into 2 groups:the control group treated with conventional wound dressing and the experimental group treated with VAC .Observations were made on various indicators at 5 different time points:i.e.before surgery, 3, 7 and 14 days after surgery, and after wound healing.Results Wound swelling and se-cretions for the animals of the experimental group were significantly improved , when they were compared with those of the control group . Removal of necrotic tissue and growth of granulation tissue were significantly accelerated .Average healing time was significantly short-ened [(16.3 ±2.6)d比(20.4 ±3.7)d)] (P<0.05).The expression levels of MMP-1 and MMP-2 mRNA in the wound tissue were significantly decreased, 3, 7 and 14 days after surgery (P<0.05), while the expression levels of TIMP-1 and TIMP-2 mRNA were sig-nificantly increased (P <0.05).The expressions of bFGF and VEGF in the serum were increased considerably (P <0.05). Conclusion Vacuum-assisted closure displayed a positive effect on the healing of radioactive ulcer of rabbits .
