Exploring the Diagnosis and Treatment Strategy for Incomplete Endothelialization After Left Atrial Appendage Closure Based on the View of Qi Flourishment Promoting Tissue Regeneration
10.13359/j.cnki.gzxbtcm.2025.11.036
- VernacularTitle:基于气旺生肌辨治左心耳封堵术后内皮化不全的思路探讨
- Author:
Huiqi ZHAI
1
;
Bowen DENG
;
Qiucen CHEN
;
Zheng JIN
;
Rong LI
;
Xiaoxiong ZHOU
;
Qingmin CHU
Author Information
1. 广州中医药大学第一临床医学院,广东 广州 510405
- Keywords:
non-valvular atrial fibrillation;
left atrial appendage closure;
incomplete endothelialization;
qi flourishment promoting tissue regeneration;
qi deficiency;
Neituo Shengji San;
traditional Chinese medicine differentiation and treatment
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2025;42(11):2877-2882
- CountryChina
- Language:Chinese
-
Abstract:
Left atrial appendage closure(LAAC)is an important intervention method for preventing thromboembolic events in patients with non-valvular atrial fibrillation(NVAF).However,incomplete endothelialization following the procedure can impact its long-term efficacy and safety.This article proposes the view of qi flourishment promoting tissue regeneration based on the traditional Chinese medicine(TCM)theory of qi and blood,and explores diagnostic and therapeutic strategies for post-LAAC incomplete endothelialization by examining the theoretical connotation of qi flourishment promoting tissue regeneration and the relationship between qi and vascular endothelial cells.It is proposed that the primary pathogenesis in patients after LAAC is due to qi deficiency.Guided by the view of qi flourishment promoting tissue regeneration,therapeutic approaches such as tonifying qi to promote granulation,supplementing qi to activate blood circulation,and harmonizing the viscera can be employed to address incomplete endothelialization in NVAF patients following LAAC.Clinically,the qi-supplementing and blood-activating classic formula Neituo Shengji San,mainly composed of Astragali Radix,Glycyrrhizae Radix et Rhizoma,Olibanum,Myrrha,Paeoniae Radix Alb,Trichosanthis Radix,Salviae Miltiorrhizae Radix et Rhizoma,etc.,is usually utilized for modified use.Depending on the specific symptom patterns or pathogenesis characteristics of patients with incomplete endothelialization,this basic formula may be used by combining with Shengmai San or augmented with qi-supplementing and blood-activating herbs such as Chuanxiong Rhizoma,Fici Simplicissimae Radix,and Notoginseng Radix et Rhizoma to promote endothelialization.Diagnosing and treating post-LAAC incomplete endothelialization in NVAF patients following the view of qi flourishment promoting tissue regeneration,it is expected to offer a novel TCM perspective and therapeutic strategy to enhance post-LAAC outcomes and address the challenge of incomplete endothelialization.This approach can further serve as a reference for TCM clinicians to manage endothelialization issues following implantation procedures.
