Data Mining Analysis of the Medication Patterns of Wu Wei in Treating Coronary Heart Disease
10.13359/j.cnki.gzxbtcm.2025.11.033
- VernacularTitle:基于数据挖掘分析吴伟治疗冠心病的用药规律
- Author:
Yanjie ZHANG
1
;
Wei WU
Author Information
1. 广州中医药大学第一临床医学院,广东 广州 510405
- Keywords:
coronary heart disease(CHD);
clearing heat and toxin-resolving;
activating blood and resolving stasis;
Salviae Miltiorrhizae Radix et Rhizoma;
Paeoniae Radix Rubra;
Chuanxiong Rhizoma;
Dalbergiae Odoriferae Lignum;
Ilex Pubescens Radix;
Carthami Flos;
Scutell
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2025;42(11):2856-2861
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the medication patterns of Professor Wu Wei,a renowned traditional Chinese medicine(TCM)expert of Guangdong Province,in treating coronary heart disease(CHD)and to provide insights for TCM clinical management of CHD.Methods From September 2015 to September 2024,the prescriptions for effective CHD cases treated by Professor Wu Wei at the Department of Cardiology,the First Affiliated Hospital of Guangzhou University of Chinese Medicine were collected.The prescription data were input into the TCM Inheritance Assistant System(V2.5).Data mining methods of frequency analysis,association rule analysis,association degree analysis,and cluster analysis were employed to analyze the usage frequencies of herbs,association rules among herbs,and potential novel formula combinations.Results A total of 200 prescriptions were included,comprising 134 medicinals.There were 28 herbs used over 15 times.The top 10 most frequently-used herbs were Salviae Miltiorrhizae Radix et Rhizoma,Paeoniae Radix Rubra,Chuanxiong Rhizoma,Dalbergiae Odoriferae Lignum,Ilex Pubescens Radix,Carthami Flos,Scutellariae Radix,Astragali Radix,Fici Simplicissimae Radix,and Bambusae Caulis in Taenia.The commonly-used medicinals can be primarily classified into blood-activating herbs,heat-clearing herbs,qi-tonifying herbs,yin-nourishing herbs,and qi-regulating herbs according to their therapeutic actions.Association rule analysis identified 27 herbal combinations used frequently,predominantly involving Paeoniae Radix Rubra,Salviae Miltiorrhizae Radix et Rhizoma,Dalbergiae Odoriferae Lignum,Chuanxiong Rhizoma,Ilex Pubescens Radix,and Carthami Flos.Association degree analysis revealed that Professor Wu Wei's prescriptions for CHD usually consisted of the combinations of blood-activating,heat-clearing,phlegm-resolving,yin-nourishing,qi-tonifying,qi-regulating,diuretic,and sedative herbs.Complex system entropy-based cluster analysis yielded seven potential novel formulas.Conclusion For the treatment of CHD,Professor Wu Wei focuses on the utilization of heat-clearing and toxin-resolving herbs and blood-activating and stasis-resolving agents,and frequently uses qi-tonifying,phlegm-resolving,qi-regulating,yin-nourishing,diuretic,and sedative herbs as the adjuvant drugs,which reflects his view of CHD's pathogenesis being heat-toxin and blood stasis and his emphasis on the clinical application of heat-clearing and blood-activating therapy.
