Optimization of Water Extraction Process of Modified Wendan Formula by Orthogonal Experiment Combined with Extraction Yields of Solids Weight Scoring Method
10.13359/j.cnki.gzxbtcm.2025.11.030
- VernacularTitle:正交试验结合总固物得率权重评分法优化加味温胆方水提工艺研究
- Author:
Muyuan CHEN
1
;
Kunyu LIU
;
Chunzhu XIE
;
Yuechun HUANG
;
Huibiao LI
;
Jie CHEN
;
Hongcheng FANG
;
Zhenwen QIU
Author Information
1. 广州中医药大学第一附属医院药学部,广东 广州 510405
- Keywords:
modified Wendan Formula;
naringin;
neohesperidin;
orthogonal experiment;
extraction process
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2025;42(11):2840-2844
- CountryChina
- Language:Chinese
-
Abstract:
Objective To optimize the water extraction process of modified Wendan Formula.Methods The comprehensive scores of the content of naringin and neohesperidin as well as the extraction yields of solids were used as the evaluation indexes,the number of decoctions,the decoction time and the solid-liquid ratio as three factors were take into consideration,L9(34)orthogonal experiment was designed to optimize the water extraction process of modified Wendan Formula.Results Combining the orthogonal experiment with the principle of energy conservation and emission reduction in actual production,this study suggests that the optimized process was under the conditions of 1∶8 for the solid-liquid ratio,decoction were performed twice,the first time was 1.5 hours,and the second time was 1 hour.The average composite score of validation of three batches of modified Wendan Formula was 99.00％.Conclusion Such optimized process was stable,feasible and realizable,and it can be applied in water extraction process of modified Wendan Formula.
