Exploring the Compatibility Patterns of Modified Sini San Formulas from the Selected Compilation of Encyclopedia of Chinese Medicinal Formulas Based on Data Mining
10.13359/j.cnki.gzxbtcm.2025.10.036
- VernacularTitle:基于数据挖掘探讨《中医方剂大辞典精选本》中四逆散加味方的配伍规律
- Author:
Weibin CHEN
1
;
Rui LI
;
Suyan CHEN
;
Xuhao WU
;
Xiaoxuan LIN
;
Qiuming CHEN
Author Information
1. 汕头市中医医院,广东汕头 515000
- Keywords:
Sini San;
modified Sini San formulas;
Selected Compilation of Encyclopedia of Chinese Medicinal Formulas;
compatibility patterns;
expanded therapeutic applications;
data mining
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2025;42(10):2611-2620
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the indications,therapeutic effects,and compatibility patterns of modified Sini San formulas.Methods Modified Sini San formulas recorded in the Selected Compilation of Encyclopedia of Chinese Medicinal Formulas were retrieved.Frequency analysis,cluster analysis,and association rule mining were performed on the herbs of Sini San modified formulas.Results A total of 34 modified Sini San formulas were included,involving 127 additional medicinals.Analysis of the properties,flavors,and meridian tropism of the top 30 high-frequency additional medicinals,including Chuanxiong Rhizoma,Angelicae Sinensis Radix,Scutellariae Radix,Cortex Magnoliae Officinalis,Rehmanniae Radix,Rhei Radix et Rhizoma,Poria,Ginseng Radix et Rhizoma,Cyperi Rhizoma,Pinelliae Rhizoma,Atractylodis Rhizoma,and Citri Reticulatae Pericarpium,revealed that the additional medicinals were predominantly warm in nature,bitter in flavor,and acted the spleen meridian.Cluster analysis yielded six categories of medicinal combinations.Association rule mining identified that Sini San was frequently prescribed by combining with single herbs of Chuanxiong Rhizoma,Angelicae Sinensis Radix,and Rehmanniae Radix,or with herbal groups of Chuanxiong Rhizoma-Angelicae Sinensis Radix,Angelicae Sinensis Radix-Rehmanniae Radix,Angelicae Sinensis Radix-Persicae Semen,Angelicae Sinensis Radix-Carthami Flos,Platycodonis Radix-Chuanxiong Rhizoma,and Carthami Flos-Persicae Semen-Angelicae Sinensis Radix.Conclusion Later physicians have expanded the application of Sini San after modification to treat externally contracted diseases with exterior syndrome,epidemic diseases,abdominal masses,eye disorders,and other conditions.Sini San is often used in combination with formulas such as Taohong Siwu Decoction and Yueju Pills.Commonly-paired additional medicinals fall into six primary categories corresponding to its expanded therapeutic applications,i.e.,stasis-resolving,blood-activating,exterior-releasing,qi-regulating,deficiency-supplementing,and purgative medicinals.The analytical results may provide new insights for modern clinical applications-pharmacological research on Sini San.
