Data Mining on Medication Patterns of Formulas Containing the Herbal Pair of Bupleuri Radix and Scutellariae Radix
10.13359/j.cnki.gzxbtcm.2025.10.035
- VernacularTitle:含柴胡-黄芩药对方剂用药规律的数据挖掘
- Author:
Yingjie AN
1
;
Junjie YAO
;
Nannan ZHANG
;
Tianying CHANG
;
Qiong ZHAO
Author Information
1. 山西中医药大学,山西晋中 030619
- Keywords:
Bupleuri Radix;
Scutellariae Radix;
herbal pair;
Glycyrrhizae Radix et Rhizoma;
Ginseng Radix et Rhizoma;
Angelicae Sinensis Radix;
Paeoniae Radix Alba;
Pinelliae Rhizoma;
exogenous febrile diseases;
heat syndrome;
ocular disorders;
data mining
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2025;42(10):2603-2611
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the composition patterns and indications of formulas containing the herbal pair of Bupleuri Radix and Scutellariae Radix(abbreviated as herbal pair Chaihu-Huangqin).Methods With Zhong Yi Fang Ji Da Ci Dian(Encyclopedia of Chinese Medicinal Formulas)as the data source,formulas containing herbal pair Chaihu-Huangqin were screened.Excel 2019,SPSS Modeler,and Cytoscape were employed to investigate the composition patterns and indications of the formulas containing the herbal pair.Results A total of 928 formulas containing the herb pair were identified,involving 293 herbs.Beyond Bupleuri Radix and Scutellariae Radix,high-frequency herbs of Glycyrrhizae Radix et Rhizoma,Ginseng Radix et Rhizoma,Angelicae Sinensis Radix,Paeoniae Radix Alba,Pinelliae Rhizoma,Gardeniae Fructus,and Poria are the primary ingredients of formulas containing herbal pair Chaihu-Huangqin.The herbs as the ingredient combinations were predominantly cold in nature and were bitter,pungent,or sweet in flavors,primarily acting on the liver and lung meridians.Association rule analysis revealed that herbal pair Chaihu-Huangqin was frequently use together with herbal groups of"Pinelliae Rhizoma-Ginseng Radix et Rhizoma-Glycyrrhizae Radix et Rhizoma"and"Poria-Ginseng Radix et Rhizoma-Glycyrrhizae Radix et Rhizoma".Formulas containing herbal pair Chaihu-Huangqin were indicated for 184 kinds of diseases,in particular for exogenous febrile diseases,heat syndrome,and ocular disorders.Complex network analysis and dosage analysis indicated that common combined herbs of Pinelliae Rhizoma,Ginseng Radix et Rhizoma,Gardeniae Fructus,and Puerariae Lobatae Radix were indicated for exogenous febrile diseases;common combined herbs of Paeoniae Radix Rubra,Coptidis Rhizoma,and Gardeniae Fructus were indicated for heat syndrome;and common combined herbs of Plantaginis Semen,Cimicifugae Rhizoma,and Cassiae Semen were indicated for ocular disorders.The dosage ratio of Bupleuri Radix-Scutellariae Radix consistently maintained a 1∶1 ratio across all above indications.Conclusion The herbal pair Chaihu-Huangqin functions to harmonize shaoyang meridian and demonstrates broad clinical applicability.The data mining study has revealed its dominant indications and combinatorial patterns,which will provide evidence-based insights for modern clinical practice.
