Observation on the Clinical Efficacy of Haloperidol Combined with Auricular Point Pressing Therapy in Children with Tic Disorders
10.13359/j.cnki.gzxbtcm.2025.10.016
- VernacularTitle:氟哌啶醇联合耳穴贴压治疗儿童抽动障碍的疗效观察
- Author:
Qing LIU
1
;
Guoyun CAO
;
Xingyue LIU
;
Rui PAN
;
Jiaming HE
;
Lei ZHANG
;
Meijia QIAN
Author Information
1. 河北省沧州中西医结合医院儿童康复科,河北沧州 061000
- Keywords:
auricular point pressing therapy;
haloperidol;
tic disorders;
children;
neurological function;
clinical observation
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2025;42(10):2470-2475
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical efficacy of haloperidol combined with auricular point pressing therapy in children with tic disorders.Methods A total of 120 pediatric patients diagnosed with tic disorders at the Department of Pediatric Rehabilitation,Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine,Hebei Province from March 2022 to March 2024 were enrolled.Participants were randomly divided into an observation group(n=60)and a control group(n=60)using a random number table.The control group received haloperidol alone,while the observation group received additional auricular point pressing therapy.Treatment duration was 12 weeks.After 3 months,clinical efficacy was assessed by comparing:Yale Global Tic Severity Scale(YGTSS)scores,serum 5-hydroxytryptamine(5-HT)and dopamine(DA)levels,immune function markers(CD3+,CD4+),and incidence of adverse reactions between groups.Results(1)The overall efficacy rate in the observation group was 91.67％(55/60),while that in the control group was 76.67％(46/60).The efficacy of the observation group was superior to that of the control group,with a statistically significant difference(P＜0.05).(2)After treatment,the YGTSS scores of children in both groups was significantly improved(P＜0.05),and the observation group showed a significantly greater improvement in YGTSS scores than the control group,with a statistically significant difference(P＜0.05).(3)After treatment,the levels of 5-HT and DA in both groups of children were significantly improved(P＜0.05),and the observation group showed a significantly greater improvement in 5-HT and DA levels than the control group,with a statistically significant difference(P＜0.05).(4)After treatment,CD3+and CD4+levels were significantly improved in both groups(P＜0.05),and the observation group showed a significantly greater improvement in CD3+and CD4+levels than the control group,with a statistically significant difference(P＜0.05).(5)There was no statistically significant difference in the incidence of adverse reactions between the observation group and the control group,with a statistically significant difference(P＞0.05).Conclusion The combination of haloperidol and auricular point pressing therapy significantly improves clinical symptoms and immune function in children with tic disorders,demonstrating both efficacy and safety.
