Clinical Efficacy of Weiwei Decoction in Chronic Atrophic Gastritis Based on the Yin-Fire Theory
10.13359/j.cnki.gzxbtcm.2025.10.012
- VernacularTitle:基于阴火学说探讨萎胃汤治疗慢性萎缩性胃炎的临床疗效
- Author:
Lintong CHEN
1
;
Lun ZHANG
Author Information
1. 广州中医药大学第五临床医学院,广东 广州 510405
- Keywords:
yin-fire theory;
Weiwei Decoction;
chronic atrophic gastritis(CAG);
deficiency-stasis and turbidity syndrome;
systemic inflammatory response;
quality of life;
precancerous gastric lesions
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2025;42(10):2442-2450
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical efficacy of Weiwei Decoction(composed of Astragali Radix,Codonopsis Radix,Angelicae Sinensis Radix,Atractylodis Macrocephalae Rhizoma,Aurantii Fructus,Dendrobii Caulis,Galli Gigerii Endothelium Corneum,Crataegi Fructus,Notoginseng Radix et Rhizoma,Curcumae Rhizoma,and Glycyrrhizae Radix et Rhizoma)in treating chronic atrophic gastritis(CAG)with deficiency-stasis blended with turbidity syndrome from the perspective of the yin-fire theory.Methods A total of 80 CAG patients with deficiency-stasis blended with turbidity syndrome were recruited from the outpatients and inpatients of the Digestive Medicine Department at Guangdong Second Traditional Chinese Medicine Hospital between October 2023 and June 2024.Patients were randomly assigned to a treatment group(n=40)or a control group(ni=40)using a random number table.The treatment group received Weiwei Decoction with modifications,while the control group received Vitacoenzyme Tablets.Both groups underwent 12 weeks of treatment.The changes in TCM syndrome scores,total gastric mucosal pathological scores and grading of gastric mucosal atrophy,intestinal metaplasia,and dysplasia,scores of 36-Item Short-Form Health Survey(SF-36),and systemic inflammatory response indices were observed,and the TCM syndrome therapeutic efficacy and drug safety were evaluated.Results(1)After 12 weeks of treatment,the overall efficacy rate in the treatment group was 85.00％(34/40),while that in the control group was 60.00％(24/40).Intergroup comparison(by chi-square test)showed that the treatment group had significantly better efficacy in terms of TCM syndromes than the control group(P＜0.05).(2)After treatment,the TCM syndrome scores of both groups decreased compared to before treatment(P＜0.05),and the decrease in the treatment group was significantly superior to that in the control group(P＜0.05).(3)After treatment,the SF-36 scores of both groups of patients increased compared to before treatment(P＜0.05),but there was no statistically significant difference between the groups in terms of the difference in scores before and after treatment(P＞0.05).(4)After treatment,the total gastric mucosal pathology score decreased in the treatment group compared to before treatment(P＜0.05),while there was no significant decrease in the control group(P＞0.05).The intergroup comparison showed that the treatment group showed a significantly greater reduction in the total gastric mucosal pathology score than the control group(P＜0.05).After treatment,the grading of gastric mucosal atrophy,intestinal metaplasia,and dysplasia in both groups were improved compared to before treatment(P＜0.05),and the improvement in the treatment group was significantly superior to that in the control group(P＜0.05).(5)After treatment,the neutrophil-to-lymphocyte ratio(NLR)and systemic immune inflammation index(SII)levels in the treatment group decreased compared to before treatment(P＜0.05),but the platelet-to-lymphocyte ratio(PLR)levels were not significantly different from pre-treatment levels(P＞0.05).The NLR,PLR,and SII levels in the control group did not show significant changes after treatment(P＞0.05).Intergroup comparisons revealed that the improvement in NLR,PLR,and SII levels in the treatment group was significantly superior to that in the control group(P＜0.05).(6)During treatment,no adverse events related to the medications were observed in either group,indicating high safety.Conclusion Weiwei Decoction significantly improves clinical symptoms,gastric mucosal pathology,quality of life,and systemic inflammation in CAG patients with deficiency-stasis blended with turbidity syndrome,and is effective on preventing the progression of precancerous gastric lesions.
